Deans' stroke musings: Role of Nitric oxide in neurodegeneration: function, regulation and inhibition

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, May 6, 2020

Role of Nitric oxide in neurodegeneration: function, regulation and inhibition

What the fuck is this trying to say? Should I be taking foods that create nitric oxide? What? How much? How often? Answers to those questions are what we need researchers to focus on. AND THAT IS WHY WE NEED SURVIVORS IN CHARGE. Nothing useful will get done otherwise. This is why reviews are useless.

Role of Nitric oxide in neurodegeneration: function, regulation and inhibition

Tewari D¹, Sah AN², Bawari S³, Nabavi SF⁴, Dehpour AR⁵, Shirooie S⁶, Braidy N⁷, Fiebich BL⁸, Vacca RA⁹, Nabavi SM⁴.

Author information

Abstract

Reactive nitrogen species (RNS) and reactive oxygen species (ROS) collectively known as reactive oxygen and nitrogen species (RONS) are the products of normal cellular metabolism and interact with several vital biomolecules including nucleic acid, proteins, and membrane lipids and alter their function in an irreversible manner which can lead finally to cell death. There is an imperative role for oxidative stress in the pathogenesis of cognitive impairments and the development and progression of neural injury. Elevated production of higher amounts of nitric oxide (NO) takes place in numerous pathological conditions such as neurodegenerative diseases, inflammation, and ischemia which occur concurrently with elevated nitrosative/oxidative stress. The enzyme nitric oxide synthase (NOS) is responsible for the generation of NO in different cells by conversion of L-arginine (Arg) to L-citrulline. Therefore, the NO signaling pathway represents a viable therapeutic target. Naturally occurring polyphenols targeting the NO signaling pathway can be of major importance in the field of neurodegeneration and related complications. Here we comprehensively review the importance of NO and its production in the human body and afterwards highlight the importance of various natural products along with their mechanisms against various neurodegenerative diseases involving their effect on NO production.