Deans' stroke musings: Circulating Metabolites Linked to Risk for Incident Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, December 18, 2020

Circulating Metabolites Linked to Risk for Incident Stroke

Will you stop doing these useless predictions and work on solutions to this supposed problem? Until we get survivors in charge this wasteful stroke research will continue. This does nothing to prevent stroke until you create solutions that prevent these.

Circulating Metabolites Linked to Risk for Incident Stroke

HealthDay News — Circulating metabolites, including amino acids, glycolysis-related metabolites, acute phase reaction markers, and lipoprotein subfractions, are associated with the risk for stroke, according to research published online Dec. 2 in Neurology.

Dina Vojinovic, Ph.D., from the University Medical Center in Rotterdam, Netherlands, and colleagues examined the association between metabolites and the risk for stroke in seven prospective cohort studies, which included 1,791 incident stroke events among 38,797 participants. Circulating metabolites were measured with nuclear magnetic resonance technology.

The researchers identified 10 significant metabolite associations. Associations with the risk for stroke were seen for amino acid histidine (hazard ratio per standard deviation, 0.90), glycolysis-related metabolite pyruvate (hazard ratio per standard deviation, 1.09), acute phase reaction marker glycoprotein acetyls (hazard ratio per standard deviation, 1.09), and cholesterol in high-density lipoprotein 2 and several other lipoprotein particles. A significant association was seen with phenylalanine (hazard ratio per standard deviation, 1.12) and total and free cholesterol in large HDL particles when focusing on incident ischemic stroke.

“Our analysis provides new insights into how the risk of stroke may be affected on the molecular level. It also raises new questions,” Vojinovic said in a statement. “Future studies are needed to further research the biological mechanisms underlying these associations between metabolites and risk of stroke.”

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One author disclosed financial ties to Nightingale Health Ltd., which offers metabolomics profiling. Several of the studies disclosed funding from the biopharmaceutical industry.

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