Your doctors and stroke hospital have had 4 years to get this tested in humans. HAVE THEY DONE ONE DAMN THING?
You do want your exercise decline reversed?
The latest here:
Osteocalcin Signaling in Myofibers Is Necessary andSufficient for Optimum Adaptation to Exercise
Mera et al., 2016, Cell Metabolism 23, 1078–1092
Authors
Paula Mera, Kathrin Laue,
Mathieu Ferron, ...,
Michelle Puchowicz, Irwin Kurland,
Gerard Karsenty
Correspondence
gk2172@cumc.columbia.edu
In Brief
Mera et al. show that the bone-derived
hormone osteocalcin is necessary for
optimum exercise capacity and that this
hormone decreases with aging in mice,
monkeys, and humans of both genders.
Osteocalcin promotes muscle uptake and
utilization of glucose and lipids during
exercise and greatly improves the
exercise capacity of old mice.
Graphical Abstract
Highlights
Bone via the hormone osteocalcin improves muscle function
during exercise
Circulating osteocalcin levels decrease in aging mice,
monkeys, and humans
Osteocalcin promotes muscle uptake and utilization of
glucose and fatty acids
Osteocalcin promotes muscle IL-6 secretion during exercise
SUMMARY
Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at
the time levels of insulin decrease. In contrast, circulating levels of osteocalcin plummet early during
adulthood in mice, monkeys, and humans of both
genders. Exploring these observations revealed
that osteocalcin signaling in myofibers is necessary
for adaptation to exercise by favoring uptake and
catabolism of glucose and fatty acids, the main nutrients of myofibers. Osteocalcin signaling in myofibers
also accounts for most of the exercise-induced
release of interleukin-6, a myokine that promotes
adaptation to exercise in part by driving the generation of bioactive osteocalcin. We further show
that exogenous osteocalcin is sufficient to enhance
the exercise capacity of young mice and to restore
to 15-month-old mice the exercise capacity of
3-month-old mice. This study uncovers a bone-tomuscle feedforward endocrine axis that favors adaptation to exercise and can reverse the age-induced
decline in exercise capacity.
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