Deans' stroke musings: POTENTIAL ROLE OF EXOSOME IN POST-STROKE REORGANIZATION AND/OR NEURODEGENERATION

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 14, 2020

POTENTIAL ROLE OF EXOSOME IN POST-STROKE REORGANIZATION AND/OR NEURODEGENERATION

I have 10 posts on exosomes back to March, 2011. Your doctors can explain their incompetency in not getting researchers to followup and create translation interventions from them.

POTENTIAL ROLE OF EXOSOME IN POST-STROKE REORGANIZATION AND/OR NEURODEGENERATION

Fateme Azizi1 , Sahar Askari2 , Pegah Javadpour2 , Mahmoudreza Hadjighassem1,4,* , Rasoul Ghasemi2,3,* 1 Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2 Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4 Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran * Corresponding authors: Rasoul Ghasemi, Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran and Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Chamran highway, Velenjak, Tehran, Iran, Phone: + 98 21 22439971, E-mail: Rghasemi60@sbmu.ac.ir; r_ghasemi60@yahoo.com Mahmoudreza Hadjighassem MD, Ph.D., Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. E-mail: mahmoudreza@hotmail.com http://dx.doi.org/10.17179/excli2020-3025 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).

ABSTRACT

Currently, stroke is a common and devastating condition, which is sometimes associated with permanent cerebral damages. Although in early time after stroke, the related treatments are mainly focused on the restoration of cerebral blood flow (CBF), at the same time, some changes are commencing that continue for a long time and need to be specially noticed. Previous studies have proposed several molecular mechanisms in these post-stroke events. Exosomes are a type of vesicle, which are formed and secreted by most cells as a mean to transfer cellular constituents such as proteins, DNA and/or RNA to distant cells. Therefore, they are considered as a novel mechanism of cellular communication. Herein, we reviewed the current knowledge on cascades, which are activated after stroke and consequently lead to the reorganization and/or continuance of tissue damage and development of other disorders such as Neurodegenerative diseases (ND). Thereafter, we summarized the latest proofs about the possible participation of exosomes in transferring some components such as proteins and micro-RNAs (miRs), from the affected areas to other parts of the brain and eventually cause the above-mentioned post-stroke events.