Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, July 17, 2023

Anti-aging therapy is one step closer after successful primate trial

This Fruit Reverses Brain Ageing - strawberries March 2018 

One Serving Of These Slows Brain Aging By 11 Years - Leafy green vegetables December 2017

 Be careful if you are on warfarin, don't do this on your own.  DEMAND your doctor get you a diet protocol because you can't do this dangerous food on your own. 

Would you rather try young blood?

OR;

  Cannabis Reverses Aging Processes in the Brain

I'll be doing this one, Michigan has approved recreational marijuana.

Eat This Once A Week To Reduce Brain Aging - seafood  November 2017 

German Study Finds Marijuana May Reverse Brain Aging, Memory Loss  May 2017

The latest here:

 

Anti-aging therapy is one step closer after successful primate trial

Boosting klotho expression after it naturally depletes could have vast anti-aging health benefits
Boosting klotho expression after it naturally depletes could have vast anti-aging health benefits
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More than 30 years after it was identified as a key ‘longevity gene,’ the protein klotho has been used to boost the cognitive function of aging rhesus macaques, paving the way for human trials.

Following on from recent mice models, an international team of scientists found that the working memory and task-completion abilities of 18 rhesus macaques (Macaca mulatta), aged an average of 22 years (the human-equivalent of around 65), was boosted when injected with the klotho protein.

The researchers include scientists from the University of California, San Francisco, Weill Institute for Neurosciences, who have focused studies on klotho and regenerative cognitive function for more than half a decade.

In the study, the monkeys had to repeatedly navigate easy and difficult mazes to find a treat, in order to see how well they remembered the most direct path. The animals repeated the tasks four hours later. after being dosed with klotho, raising the protein levels to that of juveniles. While they only showed a 6% average improvement for the easy mazes, they fared about 20% better on the harder task. The memory boost was shown to last at least two weeks.

Interestingly, the dosage was relatively much lower than in mice trials.

The transmembrane protein family klotho, which as three subfamilies, including the most often referenced alpha-klotho, was only identified in 1997 and its function is still not completely understood. However, it does play a key role in aging, regulating many of the pathways such as phosphate levels and insulin signaling.

The protein, named after the Greek goddess Clotho who spun the thread of human life, is naturally produced in the kidneys and depletes with age. Its deficiency is a factor in arterial stiffening, hypertension and vascular degeneration, among many other age-related health conditions.

Previously, studies have shown how klotho expression has boosted cognitive function in mice models, from how intermittent fasting influenced its levels to how plasma transfusions from younger to older animals resulted in muscle regeneration.

One of the current study’s co-authors, Dena Dubal compares the cognitive tests to real-world experiences like needing to remember where you left your car in a parking lot, or recalling a string of numbers, two skills that decline as you age.

Dubal, now a physician-researcher at the University of California San Francisco’s Weill Institute for Neurosciences, has been studying the life-extending potential of klotho for years.

“For humans, the end game really is: how can we increase our ‘healthspan?’” Dubal said in 2018. “And that may go hand in hand with an increase in lifespan, because the things that help us to live longer are also the things that help us to live better.”

While there’s still much unknown about the mechanisms involved in klotho’s restorative abilities, Dubal said this current research provides “a very strong reason to jump into human clinical trials now.”

The research was published in the journal Nature Aging.

Sources: NatureWeill Institute for Neurosciences, Medical Xpress

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