Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, November 7, 2011

Researchers make breakthrough in understanding white matter development

So who is going to use this to research how to fix damage of a stroke in the white matter? I know I need such help.
http://medicalxpress.com/news/2011-09-breakthroughLink-white.html
Through the identification of a gene's impact on a signaling pathway, scientists at Children's National Medical Center continue to make progress in understanding the mechanics of a key brain developmental process: growth and repair of white matter, known as myelination. The study, published online in the September 2011 online edition of The Journal of Neuroscience, identified Sox17 as the gene that helps regulate the Wnt/beta-catenin signaling pathway during the transition of oligodendrocyte progenitor cells, or immature brain cells, to a more mature, differentiated state where they generate myelin.

"This is the first time the Sox17 gene has been identified as a regulator of the Wnt/beta-catenin pathway during myelination," said Li-Jin Chew, PhD, lead author of the study. "Our findings indicate that loss of Sox17 over-stimulates the Wnt/beta-catenin pathway and keeps oligodendrocyte progenitor cells from maturing and producing myelin, potentially causing developmental disabilities in developing babies and children."

Myelin is the protective material around the axons of neurons; in mass these types of ensheathed neurons are collectively called white matter. White matter serves as the primary messaging "network" that conducts signals rapidly between gray matter areas. Without it, the brain does not function properly. Myelination, or growth of white matter, in humans begins in utero at around 5 months of gestation and continues throughout the first two decades of life. Myelination can be impaired for a number of reasons, most commonly intrauterine infection, reduced or interrupted blood flow (which carries oxygen and nutrients) to the forming infant brain, or perinatal injury. As a result, white matter doesn't develop the way that it should or is somehow damaged, resulting in mental retardation and developmental disabilities. "From here we plan to look more closely at the parts of the pathway that Sox17 regulates. We'll be able to understand the crucial molecular events that occur during oligodendrocyte development and disease," stated Vittorio Gallo, PhD, director of the Center for Neuroscience Research. "This is an incredibly exciting discovery that puts us closer to figuring out the underlying cause of white matter diseases. It also means that we may eventually understand how we could influence these pathways and possibly ease white matter damage or deficiency in our patients."

Myelination, white matter growth and repair, and the study of complex mechanisms of prenatal development are a key focus of the Center for Neuroscience Research at Children's National, which also houses the White Matter Diseases Program, one of the largest clinical programs in the country for treating children with disorders that cause the brain's to degenerate.

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