2 hours. But what about cortex locations?
http://www.cell.com/neuron/abstract/S0896-6273%2812%2900178-X
- Highlights
- Two hours of learning causes mean diffusivity reduction in the human hippocampus
- Diffusion MRI can be used to study short-term structural neuroplasticity
- Diffusion MRI changes following learning can be linked to BDNF expression
- Diffusion MRI allows multiregional assessment of structural plasticity
Summary
The timescale of structural remodeling that accompanies functional neuroplasticity is largely unknown. Although structural remodeling of human brain tissue is known to occur following long-term (weeks) acquisition of a new skill, little is known as to what happens structurally when the brain needs to adopt new sequences of procedural rules or memorize a cascade of events within minutes or hours. Using diffusion tensor imaging (DTI), an MRI-based framework, we examined subjects before and after a spatial learning and memory task. Microstructural changes (as reflected by DTI measures) of limbic system structures (hippocampus and parahippocampus) were significant after only 2 hr of training. This observation was also found in a supporting rat study. We conclude that cellular rearrangement of neural tissue can be detected by DTI, and that this modality may allow neuroplasticity to be localized over short timescales.
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