http://nnr.sagepub.com/content/26/5/479.abstract?etoc
Abstract
Background. Proof-of-principle studies have demonstrated transient beneficial effects of transcranial direct current stimulation (tDCS)
on motor function in stroke patients, mostly after single treatment sessions. Objective. To assess the efficacy of multiple treatment sessions on motor outcome. Methods. The authors examined the effects of two 5-day intervention periods of bihemispheric tDCS and simultaneous occupational/physical
therapy on motor function in a group of 10 chronic stroke patients. Results.
The first 5-day period yielded an increase in Upper-Extremity
Fugl-Meyer (UE-FM) scores by 5.9 ± 2.4 points (16.6% ± 10.6%).
The second 5-day period resulted in further
meaningful, although significantly lower, gains with an additional
improvement
of 2.3 ± 1.4 points in UE-FM compared with the end
of the first 5-day period (5.5% ± 4.2%). The overall mean change after
the 2 periods was 8.2 ± 2.2 points (22.9% ± 11.4%).
Conclusion. The results confirm the efficacy of bihemispheric
tDCS in combination with peripheral sensorimotor stimulation.
Furthermore,
they demonstrate that the effects of multiple
treatment sessions in chronic stroke patients may not necessarily lead
to a
linear response function, which is of relevance for
the design of experimental neurorehabilitation trials.
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