A press release from The University of Texas Health Science Center at Houston (UTHealth) Medical School. Whom is going to do the same testing for stroke and then in humans?
http://www.uthouston.edu/media/story.htm?id=1aa60db0-e4b5-4b5c-a450-db6fb8ffda04
A stem cell therapy previously shown to reduce inflammation in the
critical time window after traumatic brain injury also promotes lasting
cognitive improvement, according to preclinical research led by Charles
Cox, M.D., at The University of Texas Health Science Center at Houston
(UTHealth) Medical School.
The research was published in today’s issue of STEM CELLS Translational Medicine.
Cellular damage in the brain after
traumatic injury can cause severe, ongoing neurological impairment and
inflammation. Few pharmaceutical options exist to treat the problem.
About half of patients with severe head injuries need surgery to remove
or repair ruptured blood vessels or bruised brain tissue.
A stem cell treatment known as
multipotent adult progenitor cell (MAPC) therapy has been found to
reduce inflammation in mice immediately after traumatic brain injury,
but no one had been able to gauge its usefulness over time.
The research team led by Cox, the
Children’s Fund, Inc. Distinguished Professor of Pediatric Surgery at
the UTHealth Medical School, injected two groups of brain-injured mice
with MAPCs two hours after the mice were injured and again 24 hours
later. One group received a dose of 2 million cells per kilogram and the
other a dose five times stronger.
After four months, the mice receiving
the stronger dose not only continued to have less inflammation—they also
made significant gains in cognitive function. A laboratory examination
of the rodents’ brains confirmed that those receiving the higher dose of
MAPCs had better brain function than those receiving the lower dose.
“Based on our data, we saw improved
spatial learning, improved motor deficits and fewer active antibodies in
the mice that were given the stronger concentration of MAPCs,” Cox
said.
The study indicates that intravenous
injection of MAPCs may in the future become a viable treatment for
people with traumatic brain injury, he said.
Cox, who directs the Pediatric
Surgical Translational Laboratories and Pediatric Program in
Regenerative Medicine at UTHealth, is a leader in the field of
autologous and blood cord stem cells for traumatic brain injury in
children and adults. Results from a Phase I study were published in a
March 2011 issue of Neurosurgery, the journal of the Congress of
Neurological Surgeons. Cox also directs the Pediatric Trauma Program at
Children’s Memorial Hermann Hospital.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,983 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Tuesday, November 5, 2013
Stem cells linked to cognitive gain after brain injury in preclinical study
Labels:
hyperacute,
inflammation,
MAPC,
mice,
research,
stem cells,
TBI
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