This is PBA after dementia, what about after stroke? Whom is going to answer that question? ASA or NSA are you going to sponsor research to answer that f*ckingly simple question? Or are you going to continue to sit on your ass WAITING FOR SOMEONE ELSE TO SOLVE THE PROBLEM?
Dextromethorphan, Quinidine Effective
for Pseudobulbar Affect Secondary to Dementia
A fixed combination of dextromethorphan and quinidine has
demonstrated efficacy in treating pseudobulbar affect (PBA) and
depressive symptoms in patients with dementia, researchers reported here
at the 168th Annual Meeting of the American Psychiatric Association
(APA).
“The PRISM-2 is an open label study that enrolled patients with PBA
secondary to dementia, stroke, or traumatic brain injury,” explained
Andrew Cutler, MD, Florida Clinical Research Center, LLC, Sarasota,
Florida.
The analysis focused on patients form PRISM-2 who had PBA secondary
to dementia to determine if the medication had any impact on treating
any depression that patients experienced.
“The way that this medication works suggests that it will affect
mood,” said Dr. Cutler. “These were no patients who had significant
clinical depression, but they had depressive symptoms.”
PBA symptoms were significantly enhanced from study entry to the
12-week mark, with a 67.7% decrease in PBA episodes and a mean change of
-7.2 on the Center for Neurologic Study-Liability Scale (P< .001).
“By day 90, the PBA episodes were cut down to 3 a week,” said Dr.
Cutler, noting patients had multiple PBA episodes daily at study entry.
“There was tremendous improvement in episodes of PBA.”
The study also looked at depressive symptoms as measured by the
Patient Health Questionnaire-9. They found an improvement on that scale
that was statistically significant, with a change from 13.2 at study
entry to 7.4 after 12 weeks (P< .001).
Of note, there was not a direct relationship between improvement in PBA symptoms and reduction in depressive symptoms.
The most common adverse events were headache, urinary tract infection, and diarrhoea.
The study was limited by the fact that it was not randomised; rather it was an open-label design.
Funding for this study was provided by Avanir Pharmaceuticals, Inc.
[Presentation title: Dextromethorphan Quinidine for Pseudobulbar
Affect Secondary to Alzheimer’s Disease/Dementia: Effect on Mood
Symptoms in PRISM-II Dementia Cohort. Abstract P8-085]
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,116 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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