Earlier research explanation of it here:
Ischemic postconditioning as a novel avenue to protect against brain injury after stroke
The new one here:
Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia
- Elga Esposito, PhD,
- Kazuhide Hayakawa, PhD,
- Takakuni Maki, MD, PhD,
- Ken Arai, PhD and
- Eng H. Lo, PhD
+ Author Affiliations
- Correspondence to Eng H. Lo, PhD, or Elga Esposito, PhD, Massachusetts General Hospital, E Bldg 149, 13th St, Charlestown, MA 02129. E-mail lo@helix.mgh.harvard.edu or eesposito@partners.org
Abstract
Background and Purpose—Postconditioning
may be a clinically feasible way to protect the brain after a stroke.
However, its effects during the recovery
phase post stroke remain to be fully
elucidated. Here, we examine the hypothesis that ischemic
postconditioning amplifies
neurogenesis and angiogenesis during stroke
recovery.
Methods—Male
Sprague–Dawley rats were subjected to 100-minute transient middle
cerebral artery occlusion (MCAO) or postconditioning
(100-minute middle cerebral artery occlusion
plus 10-minute reperfusion plus 10-minute reocclusion). After 2 weeks,
infarct
volumes, behavioral outcomes, and
immunohistochemical markers of neurogenesis and angiogenesis were
quantified.
Results—Postconditioning
significantly reduced infarction and improved neurological outcomes.
Concomitantly, brains subjected to postconditioning
showed an increase in doublecortin/BrdU and
collagen-IV/Ki67-positive cells.
Conclusions—These results suggest that therapeutic effects of postconditioning may involve the promotion of neurogenesis and angiogenic
remodeling during the recovery phase after focal cerebral ischemia.
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