Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, August 7, 2018

Exposing Cells to the Conditions of Ischemia-Reperfusion While Oxygenation is Monitored by the CLARIOstar with ACU

Now if we could just get our researchers to determine the EXACT amount of time that reperfusion needs to occur to leave no lasting damage. With that knowledge we then have a timeframe to shoot for in tPA delivery. Right now all we know is faster is better. That is fucking useless for solving stroke. We need objective endpoints.
https://www.news-medical.net/whitepaper/20180730/Exposing-Cells-to-the-Conditions-of-Ischemia-Reperfusion-While-Oxygenation-Is-Monitored-by-the-CLARIOstar-with-ACU.aspx
Jul 30 2018
Life-threatening diseases such as myocardial infarction, stroke, or renal failure can occur due to interrupted oxygen flow. Cells and tissues are temporarily deprived of O2 (ischemia) and develop survival-strategies.
Additionally, upon re-oxygenation (reperfusion), cells are exposed to an additional threat by sudden oxygen increase. Despite being critical for survival, sudden reperfusion of tissue creates an inflammatory response and oxidative stress..
A trial set-up which mimics rapid fluctuations in O2 level is needed for assessment of biological effects of ischemia-reperfusion.
A microplate reader with software-regulated CO2 and O2 flow is employed in the ischemia-reperfusion model shown here. Fluctuations in oxygenation of Cor.4U® cardiomyocytes and HepG2 cells were recorded using an intracellular oxygen-sensitive fluorescent probe .
Read the full article including the methods, results and discussion.
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