This type of review should never be necessary. All stroke research should update that public database so that the database is always the latest and greatest. Businesses figured that out decades ago.
Effectiveness of neuromuscular electrical stimulation combined with rehabilitation training for treatment of post-strokelimb spasticity
doi: 10.1097/MD.0000000000017261
Research Article: Study Protocol Systematic Review
Open
Background: This study aims to systematically explore the effectiveness of neuromuscular electrical stimulation (NMES) combined with rehabilitation training (RT) for the treatment of post-stroke limb spasticity (PSLS).
Methods: We will search Cochrane Library, MEDILINE, EMBASE, CINAHL, AMED, PsycINFO, WOS, Scopus, OpenGrey, and 4 Chinese databases from inception to the present without language restrictions. We will only consider randomized controlled trial on assessing the effectiveness and safety of NMES combined with RT for the treatment of PSLS. All included randomized controlled trials will be assessed using Cochrane risk of bias tool. Two researchers will independently perform study selection, risk of bias assessment, and data extraction, respectively. Any disagreements will be solved by a third researcher through discussion.
Results: Primary outcome is limb spasticity status. Secondary outcomes comprise of limb function, quality of life, and adverse events.
Conclusion: This study will summarize the latest evidence of NMES combined with RT for the treatment of patients with PSLS.
Systematic review registration: PROSPERO CRD42019138900.
Methods: We will search Cochrane Library, MEDILINE, EMBASE, CINAHL, AMED, PsycINFO, WOS, Scopus, OpenGrey, and 4 Chinese databases from inception to the present without language restrictions. We will only consider randomized controlled trial on assessing the effectiveness and safety of NMES combined with RT for the treatment of PSLS. All included randomized controlled trials will be assessed using Cochrane risk of bias tool. Two researchers will independently perform study selection, risk of bias assessment, and data extraction, respectively. Any disagreements will be solved by a third researcher through discussion.
Results: Primary outcome is limb spasticity status. Secondary outcomes comprise of limb function, quality of life, and adverse events.
Conclusion: This study will summarize the latest evidence of NMES combined with RT for the treatment of patients with PSLS.
Systematic review registration: PROSPERO CRD42019138900.
1 Introduction
Post-stroke limb spasticity (PSLS) is a very common complication among stroke survivors.[1–3]
This disorder often involves in voluntary movement, which greatly limit
the mobility and functional ability of patients with PSLS, and can
decrease their quality of life.[4–7] It has been estimated that the prevalence of PSLS is 19% to 42.6%,[7,8] and its disabling spasticity varies from 2% to 13%.[9] To treat patients with PSLS, a number of different managements such as neuromuscular electrical stimulation (NMES), rehabilitation training (RT), local botulinum toxin injection, and surgical interventions have been commonly utilized in clinic.[3,10–16]
However, the efficacy of those single treatments is still limited.
Thus, it is very important to use combined approaches to treat this
disorder, such as NMES combined with RT. Although several clinical
studies have reported that the efficacy of NMES plus RT is encouraging,[3,12,17–20] the conclusion is still unclear. Therefore, this systematic review will systematically assess the efficacy and safety of NMES combined RT for patients with PSLS.
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