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Abstract
Background and Purpose—
Information
on what effect disability before stroke can have on stroke outcome is
lacking. We assessed prestroke disability in relation to poststroke
hospital outcome.
Methods—
Analysis
of prospectively collected data from the Sentinel Stroke National Audit
Programme. A total of 1656 men (mean age ±SD =73.1±13.2 years) and 1653
women (79.3±13.0 years) were admitted to hyperacute stroke units with
acute stroke in 4 major UK between 2014 and 2016. Prestroke disability,
assessed by modified Rankin Scale (mRS), was tested against poststroke
adverse outcomes, adjusted for age, sex, and coexisting morbidities.
Results—
Compared
with patients with prestroke mRS score =0, individuals with prestroke
mRS scores =3, 4, or 5 had greater adjusted risks of moderately severe
or severe stroke on arrival (4.4% versus 16.7%; odds ratio [OR], 3.2
[95% CI, 2.3–4.6] P<0.001); urinary tract infection or pneumonia within 7 days of admission (9.6% versus 35.9%; OR, 3.7 [95% CI, 2.8–4.8] P<0.001); mortality (7.2% versus 37.1%; OR, 4.9 [95% CI, 3.7–6.5] P<0.001); requiring help with activities of daily living on discharge (12.3% versus 26.7%; OR, 3.1 [95% CI, 2.3–4.1] P<0.001); and transferred to new care home (2.4% versus 9.4%; OR, 2.1 [95% CI, 1.3–3.3] P=0.002).
Patients with mRS scores =1 or 2 had intermediate risk of adverse
outcomes. Overall, those with a mRS score =1 or 2 had length of stay on
hyperacute stroke units extended by 5.3 days (95% CI, 2.8–7.7; P<0.001) and mRS score =3, 4 or 5 by 7.2 days (95% CI, 4.0–10.5; P<0.001).
Conclusions—
Individuals
with evidence of prestroke disability, assessed by mRS, had
significantly increased risk of post stroke adverse outcomes and longer
length of stay on hyperacute stroke units and higher level of care on
discharge.
Footnotes
Correspondence
to Thang S. Han, MD, PhD, Royal Holloway, University of London,
Biological Sciences, Bourne Laboratory, Egham TW20 0EX, United Kingdom.
Email
t.s.han@doctors.org.uk
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