Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, June 27, 2025

Nitric Oxide as a Determinant of Human Longevity and Health Span

Didn't your competent? doctor create a protocol for this a long time ago? Why not?

Do you prefer your doctor and hospital incompetence NOT KNOWING? OR NOT DOING?

  • nitric oxide (121 posts to March 2011)
  • endothelial nitric oxide (2 posts to January 2019)
  • nitric oxide generator (1 post to July 2022)
  • nitric oxide pathways (1 post to July 2021)

    • Nitric Oxide as a Determinant of Human Longevity and Health Span            

                                     by 1,*, 2, 3 and 4
    1
    Department of Physiology, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, Faculty of Biology and Psychology, Georg August University Göttingen, Zappenburg 2, D-38524 Sassenburg, Germany
    2
    Indian Scientific Education and Technology Foundation, Lucknow 226002, India
    3
    Department of Neurobiology, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    4
    Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    *
    Author to whom correspondence should be addressed.
    Int. J. Mol. Sci. 2023, 24(19), 14533; https://doi.org/10.3390/ijms241914533
    Submission received: 31 August 2023 / Revised: 20 September 2023 / Accepted: 22 September 2023 / Published: 26 September 2023
    (This article belongs to the Special Issue The 25th Anniversary of NO)
    Browse Figures
    Review Reports Versions Notes

    Abstract

    The master molecular regulators and mechanisms determining longevity and health span include nitric oxide (NO) and superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between the dangerous SOR and the protective NO radical to promote healthy aging. Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. Uncoupling of NO generation with the appearance of SOR can be induced by asymmetric dimethylarginine (ADMA). L-arginine can displace ADMA from the site of NO formation if sufficient amounts of the amino acid are available. Antioxidants such as ascorbic acids can scavenge SOR and increase the bioavailability of NO. The topics of this review are the complex interactions of antioxidant agents with L-arginine, which determine NO bioactivity and protection against age-related degeneration.
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