Ask your competent? doctor if this would prevent muscle atrophy post stroke. Doesn't know! You DON'T have a functioning stroke doctor if your doctor doesn't have a protocol to prevent muscle atrophy/sarcopenia!
Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects
Abstract
Urolithin A (UA) is a naturally occurring compound derived from the metabolism of gut microbiota, which has attracted considerable research attention due to its pharmacological effects and potential implications in muscle health and performance. Recent studies have demonstrated that Urolithin A exhibits diverse biological activities, encompassing anti-inflammatory, antioxidant, anti-tumor, and anti-aging properties. In terms of muscle health, accumulating evidence suggests that Urolithin A may promote muscle protein synthesis and muscle growth through various pathways, offering promise in mitigating muscle atrophy. Moreover, Urolithin A exhibits the potential to enhance muscle health and performance by improving mitochondrial function and regulating autophagy. Nonetheless, further comprehensive investigations are still warranted to elucidate the underlying mechanisms of Urolithin A and to assess its feasibility and safety in human subjects, thereby advancing its potential applications in the realms of muscle health and performance.
Keywords: Urolithin A, muscle health, muscle performance, pharmacology, review
1. Introduction
In recent years, there has been a substantial increase in the recognition of the critical importance of both health and athletic performance [1,2]. The pursuit of muscle health and optimal athletic performance is no longer confined solely to athletes or fitness enthusiasts but has become a pervasive goal among the general population, who strive for a healthier and more active lifestyle [3,4]. Consequently, there is a widespread demand for strategies to enhance muscle health and improve athletic performance, rendering this field an area of profound discussion and extensive research.
Urolithin A, a naturally occurring compound derived from dietary sources, has swiftly emerged as a prominent subject of investigation in the context of muscle health and performance [5,6,7]. Existing evidence supports the potential of Urolithin A in facilitating muscle cell proliferation and augmenting muscle function (Figure 1) [8,9,10]. However, the understanding of the mechanisms of action and potential applications of Urolithin A as it relates to muscle health and athletic performance is still in its infancy.
Figure 1.
Pharmacological effects of Urolithin A and its role in promoting muscle health and enhancing athletic performance.
The present review aims to provide a comprehensive survey and analysis of current research on the impact of Urolithin A on muscle health and performance, as well as suggest directions for future research. The topic will be examined from multiple perspectives, consolidating and assessing existing experimental outcomes to unravel the correlation between Urolithin A, muscle health, and corresponding biological processes and molecular mechanisms. Furthermore, potential areas of application of Urolithin A, including its feasibility as a dietary supplement or pharmaceutical product, will be discussed. This paper, grounded in an extensive literature review and systematic analysis, seeks to synthesize current research findings to offer fresh insights into the role of Urolithin A in muscle health and performance. It is anticipated that these insights may provide valuable guidance for further exploration into the functional mechanisms of Urolithin A, ultimately facilitating the development of innovative strategies to enhance muscle health.
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