Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, June 28, 2025

Sleep Learning: How Synapses Strengthen While We Rest

Since 30% of survivors have sleep problems, has your doctor done ONE DAMN THING about it in the last 5 years? NO? So, you don't have a functioning stroke doctor, do you?

Is your doctor suggesting either of these? Never mind, way too soon for your doctor to read, understand and implement these interventions. Maybe 50 years from now. Of course your doctor needs to get this testing done on stroke survivors if they are competent at all!

Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomized, double-blind, placebo-controlled trial June 2020

Pink Noise Machines Improve Sleep & Fight Dementia  June 2020

 Or is your doctor so incompetent that s/he is not even trying to create recovery protocols for stroke survivors? Mine knew nothing and did nothing as proven by writing three prescriptions of E.T.(Evaluate and Treat to the therapists. I could train a chimp to do that!

In my opinion competence is immediately installing protocols upon published research. Does your incompetent? doctor think that is too high a bar? FIRE THEM! And if your doctor is still there after doing nothing your board of directors is completely incompetent!

 The latest here:

Sleep Learning: How Synapses Strengthen While We Rest

Summary: New research reveals how synaptic connections in the cerebral cortex can strengthen during sleep, offering insight into how the brain continues learning even while we rest. Using computer simulations, researchers demonstrated that synaptic activity during sleep follows known “synaptic learning rules” when neural activity reaches specific thresholds.

This means that under certain conditions, learning can occur during sleep—a concept long speculated but now theoretically supported. The findings may also shed light on sleep-related brain disorders and pave the way for new strategies in cognitive health and memory enhancement.

Key Facts:

  • Sleep-Driven Plasticity: Synaptic strength can increase during sleep if certain activity thresholds and learning rules are met.
  • Theoretical Sleep Learning: The study predicts conditions under which “sleep learning” is scientifically plausible.
  • Clinical Relevance: Insights could inform understanding and treatment of sleep-linked brain disorders like neuropsychiatric diseases.

Source: Japan Science and Technology Agency

In the cerebral cortex, numerous neurons exchange information through junctions known as synapses. The strength of each synaptic connection changes depending on the activity levels of the neurons involved, and these changes are thought to form the basis of learning and memory.

There are several established principles governing the relationship between neuronal activity patterns and changes in synaptic strength, referred to as “synaptic learning rules” (1).

Although it is well known that sleep plays a crucial role in learning and memory, how synaptic connections are altered during sleep has remained unclear.

A research group led by Professor Hiroki Ueda of the Graduate School of Medicine, The University of Tokyo, has demonstrated that the strength of synaptic connections in the cerebral cortex during sleep changes depending on synaptic learning rules and the level of neuronal activity during sleep.

They revealed that it was possible to theoretically predict the conditions under which “sleep learning (2) ” may occur.

The researchers used computational simulations to reproduce the activity of neural networks composed of various types of interconnected neurons, and they investigated changes in synaptic connections during the neural activity observed in the sleep-wake states.

These results showed that synaptic connections in the cerebral cortex are strengthened during sleep when specific levels of neural activity were accompanied by typical synaptic learning rules.

This finding clarified the conditions under which synaptic strengthening can occur even during sleep, thereby enabling theoretical predictions of when “sleep learning” is possible.

Based on these predictions, these insights are expected to lead to a deeper understanding of the relationship between sleep, learning and memory.

Moreover, they may contribute to elucidating the mechanisms of brain disorders associated with sleep disturbances, such as neuropsychiatric conditions.

These findings were published in the online version of the American scientific journal PLOS Biology on June 12, 2025.

This result was achieved in the Ueda Biological Timing Project, a research area of the Exploratory Research for Advanced Technology (ERATO) by the Japan Science and Technology Agency (JST). Under this project, JST pursues “systems biology for understanding humans” using the sleep-wake rhythm as a model system and aims to understand information on “biological time,” which transcends from molecules to individual humans livingin society.

Notes:

(*1) Synaptic learning rules

Rules that describe how the strength of synaptic connections between neurons changes depending on the timing and frequency of neural activity. Examples include Hebbian rule and spike-timing-dependent plasticity (STDP).

(*2) Sleep learning

The enhancement of memory and learning performance through the organization and integration of new information by the brain during sleep.

About this sleep and learning research news

Author: Satomi Kobayashi
Source: Japan Science and Technology Agency
Contact: Satomi Kobayashi – Japan Science and Technology Agency
Image: The image is credited to Neuroscience News

Original Research: Open access.
A unified framework to model synaptic dynamics during the sleep–wake cycle” by Hiroki Ueda et al. PLOS Biology

No comments:

Post a Comment