Deans' stroke musings: Impact of actigraphy-based circadian rest-activity rhythms on functional outcomes in post-stroke rehabilitation

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, September 26, 2025

Impact of actigraphy-based circadian rest-activity rhythms on functional outcomes in post-stroke rehabilitation

I'm sure your competent? doctor isn't keeping up-to-date with the

Journal of the Formosan Medical Association

Impact of actigraphy-based circadian rest-activity rhythms on functional outcomes in post-stroke rehabilitation

https://doi.org/10.1016/j.jfma.2025.09.030 Get rights and content

Under a Creative Commons license

Open access

Abstract

Background/Purpose

This prospective observational study investigated the relationship between circadian rest-activity rhythms and functional outcomes in subacute stroke rehabilitation.

Methods

A cohort of 70 subacute stroke patients (32.9 % female; mean age 67.1 ± 12.2 years) was assessed. Actigraphy data collected over seven days were used to calculate rest-activity rhythm indicators, including interdaily stability (IS), intradaily variability, relative amplitude, and the 10 most active and five least active continuous hours. Correlations between these indicators and functional outcomes, measured by the Barthel Index (BI) at discharge, were analyzed.

Results

Significant associations were identified between rest-activity rhythm indicators and functional outcomes. By univariate analysis, IS demonstrated positive correlations with BI scores at admission (r = 0.32, P = 0.007) and at discharge (r = 0.46, P < 0.001), whereas relative amplitude and the 10 most active continuous hours also showed positive correlations with BI scores at both time points. By multivariate analysis, after adjusting for age, sex, BI score, cognition, stroke severity at admission, and other rest–activity rhythm indicators, IS was an independent predictor of discharge BI scores (β = 0.23, P = 0.013).

Conclusion

Circadian rest-activity rhythm indicators are significantly associated with functional recovery in post-stroke patients. These findings highlight the negative impact of circadian disruptions on rehabilitation outcomes and suggest that actigraphy-derived metrics could serve as promising digital biomarkers to guide interventions and enhance outcomes.