Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, September 24, 2025

The Microbiota–Gut–Brain Axis Theory: a new perspective to unlock the pathological mechanism of constipation

 

Here's a vicious circle your competent? doctor has to navigate. The best solution would be 100% recovery and getting back to your daily life, but that won't occur, your doctor has been incompetent in getting research done for 100% recovery.

You'll have to break thru your doctor's reluctance.

The latest here:

The Microbiota–Gut–Brain Axis Theory: a new perspective to unlock the pathological mechanism of constipation


https://doi.org/10.1016/j.prp.2025.156236Get rights and content

Highlights

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    To reveal the pathological mechanism of gastrointestinal diseases such as constipation via the MGB axis.
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    Specific regulatory processes of the MGB axis in the neuroendocrine pathway, metabolism pathway and immune pathway.
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    Serotonin has been identified as a central regulator of constipation progression via gut-brain axis signaling.
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    This study provides new ideas for the treatment of constipation and other gastrointestinal diseases.

Abstract

Constipation, a common gastrointestinal system disease, has a variety of side effects, but its pathogenesis is diverse and complex. Thus, its treatment is affected by a variety of factors, such as intestinal flora imbalance, nervous system problems (cerebrovascular disease, cognitive impairment or dementia, Parkinson’s disease) and other pathological diseases (hypothyroidism, hypercalcemia and others). With the rise of the microbiota-gut-brain (MGB) axis theory, people's understanding and treatment methods for gastrointestinal diseases such as constipation have also undergone significant changes. Therefore, this paper focuses on the MGB axis and constipation, including the 3 main regulatory pathways of this axis, the gut microbial metabolites and the regulation of neurotransmitters, and the methods and applications of treating constipation and other diseases on the basis of this axis. Further clarification of the pathways and influencing factors related to the MGB axis will help elucidate the pathophysiological mechanisms of constipation and play a key role in the rational treatment of human gastrointestinal diseases.
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