Deans' stroke musings: Sulforaphane and Gut-Brain Axis: An Overview of Its Impact on Intestinal Inflammation, Microbiota Composition, and NeurodegenerationCli

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 28, 2025

Sulforaphane and Gut-Brain Axis: An Overview of Its Impact on Intestinal Inflammation, Microbiota Composition, and NeurodegenerationCli

Will your competent? doctor get the dietician to update your diet protocols with this information? Oh, you DON'T HAVE A DIET PROTOCOL, DO YOU? Incompetence of both the hospital and doctor! Haven't you fired both yet?

Sulforaphane and Gut-Brain Axis: An Overview of Its Impact on Intestinal Inflammation, Microbiota Composition, and Neurodegeneration

Sachin Sharma Rakesh Sharma * Anil Kumar Verma

Abstract

Sulforaphane (or SFN), an isothiocyanate bioactive compound synthesized from methionine, is mostly found in cruciferous vegetables like cabbage, Brussels sprouts, broccoli, etc. Upon consumption, a spontaneous reaction of SFN with glutathione (GSH) triggers the mercapturic acid pathway through which SFN is metabolized primarily in the liver and gastrointestinal tract. Also, SFN is unstable and degradable, and its production is easily affected by temperature, pH, and enzyme activity, which limits its application. Hence, in recent years, several studies have focused on the extraction and purification of SFN using novel techniques to optimize an easy-to-scale protocol that can also prevent the degradation of SFN. SFN is sought after due to its high bioavailability and therapeutic effects as a chemopreventive agent. However, this study focuses on the lesser-known beneficial effects of SFN on the gut-brain axis through which it can alleviate inflammatory bowel diseases, gut dysbiosis, neuroinflammation, and neurodegenerative diseases. SFN reduces the transcription of nuclear factor kappa B, production of pro-inflammatory cytokines, and alleviates gut dysbiosis by reducing the Firmicutes/Bacteroidetes ratio and pathogenic gut microbes, along with increasing the production of anti-inflammatory cytokines, tight junction proteins, and neurotransmitters. Furthermore, SFN can activate nuclear factor erythroid-derived 2 and antioxidant response elements, producing phase II antioxidant enzymes and reducing the accumulation of α-synuclein, tau, etc. Hence, this review examines sulforaphane, its extraction, metabolism, mechanism of action, and importance in the gut-brain axis.

Abstract Image