Deans' stroke musings: DMT Shows Promise in Protecting the Brain After Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, September 27, 2025

DMT Shows Promise in Protecting the Brain After Stroke

WHOM do we contact to get immediate action on this?

Let's see how long YOUR DOCTOR HAS BEEN INCOMPETENT ON THIS! Only 5 years, and still has a job?

Doesn't your doctor read the literature?

DMT (8 posts to November 2020)

DMT Shows Promise in Protecting the Brain After Stroke

Summary: New research shows that DMT, a natural psychoactive compound found in plants and the human brain, can protect against stroke damage in animal and cell models. Treatment with DMT reduced infarct size, brain swelling, and inflammation, while also repairing blood-brain barrier function.

The compound acted through Sigma-1 receptors to limit microglial activation and support astroglial cells, creating a dual protective effect. These findings suggest DMT could one day serve as an adjuvant therapy for stroke, expanding treatment options and improving recovery outcomes.

Key Facts

Barrier Protection: DMT restored blood-brain barrier integrity after stroke.(Solving this problem? Inflammatory action leaking through the blood brain barrier.)
Inflammation Control: It reduced cytokine production and microglial activation.
Therapeutic Potential: Could complement limited existing stroke treatments.

Source: HUN-REN BRC

DMT, or dimethyltryptamine is a natural psychoactive molecule found in many plants and mammals.

According to an article published in Science Advances, researchers from the HUN-REN BRC Institute of Biophysics and Semmelweis University Heart and Vascular Centre found that DMT reduces the harmful effects of stroke in animal models and cell culture experiments.

A solution from nature in the spotlight

DMT is also present in the human brain, and it is currently undergoing clinical trials to aid recovery of brain function after stroke. However, its exact mechanism of action had not been fully understood until now. “It is amazing how we can always turn to Nature to find ingenious solutions for health problems” says co-lead author Mária Deli from the HUN-REN BRC.

The blood-brain barrier as a therapeutic target

“We found that DMT significantly reduced infarct volume and edema formation in a rat stroke model”, explains co-first author Marcell László.

In both animal experiments and cell culture models, the authors showed that DMT treatment restored the structure and function of the damaged blood-brain barrier and improved the function of astroglial cells.

This psychoactive compound also inhibited the production of inflammatory cytokines in brain endothelial cells and peripheral immune cells, while reduced the activation of brain microglia cells through Sigma-1 receptors.

DMT could serve as therapeutic adjuvant to existing stroke treatments

“The therapeutic options currently available for stroke are very limited. The dual action of DMT, protecting the blood-brain barrier while reducing brain inflammation, offers a novel, complex approach that could complement existing treatments”, says Judit Vigh, co-first author of the work.

Since current stroke therapies do not always result in full recovery, a DMT-based treatment may represent a promising new alternative, mainly in combination with existing methods.

The recent findings from researchers in Szeged and Budapest, Hungary, support the development of a therapy that goes beyond the limitations of conventional stroke treatment. Clinical trials on the use of DMT and investigation on its long-term effects are currently ongoing.