Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, September 27, 2025

Prozac May Rewire the Brain by Loosening Rigid Neural Circuits

 

 And EXACTLY WHY WAS THIS STUDY DONE? This study from January 2019 already came to this conclusion; 

Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function. Study here:

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised,controlled trial   January 2019

Other studies here which your competent? doctor better be extremely familiar with. I suggest testing your doctor for competence in this. Failure and the doctor is fired! 

  • prozac (3 posts to May 2014)
  • fluoxetine (23 posts to May 2014)


    • Prozac May Rewire the Brain by Loosening Rigid Neural Circuits

    Summary: A new study shows that fluoxetine, better known as Prozac, does more than increase serotonin—it changes how brain cells handle energy and rebuild connections. After two weeks of treatment, parvalbumin interneurons in the prefrontal cortex became less rigid, with mitochondrial energy genes reduced and plasticity genes upregulated.

    The protective perineural nets that normally limit flexibility also weakened, allowing circuits to adapt more easily. These changes suggest fluoxetine may help treat depression by creating a more flexible brain state, paving the way for recovery.

    Key Facts

    • Cellular Target: Fluoxetine reduces rigidity in parvalbumin interneurons.
    • Mitochondrial Shift: Genes for energy production drop, while plasticity genes rise.
    • Plasticity Boost: Weakened perineural nets may allow neural circuits to rewire.

    Source: University of Eastern Finland

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