Researchers Prolong Brain Healing Window Post-Stroke

 Do your really think your incompetent? doctor and hospital will get further research going on this? Then you're living in la-la land!

Of course, just to prove the point your incompetent? doctor did nothing with all this earlier IGF-1 research!

Your fuckingly incompetent? doctor DID NOTHING WITH ALL THIS EARLIER RESEARCH! And you still see them?

IGF-1 (21 posts to March 2014)

Researchers Prolong Brain Healing Window Post-Stroke

ZFP384 inhibition prolonged brain repair and improved recovery in stroke models.

Blocking the activity of ZFP384 can prolong the brain’s endogenous repair functions after stroke, report researchers in a collaborative study. They developed an antisense oligonucleotide-based therapy that sustained the reparative activity of microglia by promoting remyelination and neural plasticity, thereby improving functional recovery in mice. Surprisingly, these results were observed even when the treatment began weeks after injury. The findings reveal a promising strategy to extend the brain’s recovery window after stroke, improving long-term outcomes.

Stroke is one of the leading causes of long-term disability worldwide, which often results in impairments in movement, speech, and cognition in patients. While rehabilitation helps patients regain some lost functions, the brain’s natural ability to repair itself often fades within a few months after an injury. This limited period of spontaneous recovery poses a major challenge for patients, often resulting in permanent neurological deficits after the brain’s intrinsic repair capacity declines. Although this loss of reparative ability has been studied extensively, the mechanism behind this loss remains unclear.

To uncover the reason why this happens, a team led by Assistant Professor Jun Tsuyama and Professor Takashi Shichita from the Department of Neuroinflammation and Repair, Institute of Science Tokyo (Science Tokyo), Japan, conducted research in collaboration with researchers from the Tokyo Metropolitan Institute of Medical Science, Kyushu University, Japan, and the University of Freiburg, Germany. Their findings were published in the journal Nature on May 13, 2026.

After a stroke, the brain launches a coordinated repair program that involves several types of cells. Among these, microglia, the brain’s resident immune cells, play a pivotal role. Immediately after an injury, microglia are activated to trigger inflammation, but thereafter, they rapidly transition into a reparative state and produce growth factors, such as insulin-like growth factor 1 (IGF1), which support remyelination, strengthen neural connections, and promote functional recovery. But this only lasts for two months, limiting the brain’s capacity to repair further.