Associations between wearable‐device‐measured daytime and nighttime light exposures and dementia risk: A prospective cohort study

 Not getting you into daylight as often as possible IS EXTREME INCOMPETENCE OF YOUR DOCTOR!

Associations between wearable‐device‐measured daytime and nighttime light exposures and dementia risk: A prospective cohort study

Nana Zheng 1,2,3, Wei Wang 2,3,4, Biao Li 2,3, Xionge Mei 2,3, Yue Liu 5, Jing Du 2,3, Ngan Yin Chan 6,7, Joey W Y Chan 6,7, Xiaoman Xing 8, Xiao Tan 9, Christian Benedict 10, Yun Kwok Wing 6,7, Jihui Zhang 2,3,6,7,11,✉, Hongliang Feng 2,3,4,11,✉

PMCID: PMC13291554  PMID: 42358626

ABSTRACT

Background

Identifying reliable predictors for dementia remains a critical unmet need(You ARE that blitheringly stupid you think predictions are helpful! SOLVE THE CORRECT PROBLEM! PREVENTING DEMENTIA!) Light exposure plays a crucial role in regulating circadian rhythms, which influence cognitive function. However, the association between light exposure and dementia risk remains unclear.

Aims

This study examined the associations of daytime and nighttime light exposure with dementia risk.

Methods

A total of 87 577 dementia‐free participants (mean age: 62.36 years; 56.98% female) were included. Daytime and nighttime light exposures were measured using 7‐day free‐living wrist‐worn accelerometry. Incident dementia was identified from primary care, hospital inpatient admissions and death registry data. Cox proportional hazards models assessed associations, and mediation analyses evaluated circadian rest–activity rhythms (CRARs), brain structures and vitamin D as potential mediators.

Results

Over a median follow‐up of 8.1 years, 741 participants developed dementia. Daytime light exposure above 1000 lux was associated with reduced dementia risk (hazard ratio [HR] 0.84, 95% confidence interval [CI] 0.71–0.99, p = 0.039). Longer exposure to brighter light (e.g., ≥ 0.70 h at ≥ 5000 lux; HR 0.83, p = 0.036) was associated with a further reduction in risk. In exploratory analyses, CRARs and brain structures mediated up to 33% of the association. Protective associations were stronger in those with high levels of nighttime light exposure, an evening chronotype or apolipoprotein E (APOE) ε4 carrier status, with a risk reduction of up to 41%. Furthermore, < 0.70 h per day of bright daytime light (≥ 5000 lux) outperformed six established dementia predictors (e.g., obesity, alcohol consumption, traumatic brain injury and so on). Nighttime light showed no significant association with dementia risk.

Conclusions

High levels of daytime light exposure were significantly associated with lower dementia risk. Further research should explore its role in dementia screening and inform the development of light‐based interventions.