Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, March 11, 2011

neurotransmitter reboxetine could improve post-stroke rehabilitation

http://www.mpg.de/1206132/noradrenaline_stroke?filter_order=L
In many patients, fine motor skills remain impaired after a stroke. A recent study has shown that the neurotransmitter noradrenaline may be able to reduce such deficits. This finding could result in the development of a new therapeutic approach to the post-stroke rehabilitation of patients.
 Brain connectivity following the administration of reboxetine
© C. Grefkes, MPI for Neurological Research As part of the study carried out by Christian Grefkes from the Max Planck Institute for Neurological Research in cooperation with scientists from the Institute of Neurosciences and Medicine of the Forschungszentrum Jülich and the Department of Neurology of the University Hospital of Cologne, eleven stroke patients (between 42 and 74 years old) with fine motor deficits carried out a range of motor tasks which involved the determination of maximum grip power and finger-tapping frequency and the execution of pointing movements.
The researchers influenced the dwell time of the naturally released neurotransmitter noradrenaline by administering reboxetine (RBX) to the patients. This substance slows down the reuptake of the transmitter by neurons and hence extends its stimulating effect on coupling within the cortical motor network. As a control condition, some patients were given a pill that looked the same, but contained no active substance (placebo).
On the behavioural level, the extended dwell time of the noradrenaline prompted an improvement in the patients’ performance of simple motor tests: while grip power in the affected hand increased by a factor of four on average, the finger-tapping frequency doubled – this represents a remarkable improvement from both the patients’ and neurologists’ point of view. As indicated by functional magnetic-resonance imaging scans (fMRI), the improvements in motor performance were associated at cortical level with a normalisation of the previously abnormally increased brain activity – particularly in the motor areas of the damaged brain hemisphere. These processes were accompanied by greater communicative efficiency between the hand area and the brain’s motor control centres.
Max Planck junior scientist Christian Grefkes is optimistic about the results: “The findings of our study could provide a starting point for the development of a promising new therapeutic approach to the correction of defects in brain networks and improvement of hand motor functions following a stroke”. The plan is now to test reboxetine on a larger group of patients over a period of several weeks to establish the sustainability of the improved effects.

Very interesting but I wonder if this is just for acute or could I as a chronic survivor benefit from this?  This one says it is for chronic
http://www.ncbi.nlm.nih.gov/pubmed/17277911
Who's willing to follow up with more detailed human testing?

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