This one is heavy going but they do talk about pericytes, which is a cause of neuronal death, and filopodia signaling. They should have been able to summarize it in a couple of sentences or at least farmed it out to a neurologist well-versed in stroke to get his/her take on it.
This is not directly related to stroke but to me it is invaluable to understand it.
http://www.hindawi.com/journals/ijvm/2012/293641/
abstract only, read the whole thing at the url.
AbstractAs our understanding of molecular mechanisms leading to vascular formation increases, vessel maintenance including stabilization of new vessels and prevention of vessel regression began to be considered as an active process that requires specific cellular signaling. While signaling pathways such as VEGF, FGF, and angiopoietin-Tie2 are important for endothelial cell survival and junction stabilization, PDGF and TGF-β signaling modify mural cell (vascular smooth muscle cells and pericytes) functions, thus they fortify vessel integrity. Breakdown of these signaling systems results in pathological hyperpermeability and/or genetic vascular abnormalities such as vascular malformations, ultimately progressing to hemorrhage and edema. Hence, blood vessel maintenance is fundamental to controlling vascular homeostasis and tissue functions. This paper discusses signaling pathways essential for vascular maintenance and clinical conditions caused by deterioration of vessel integrity.
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