http://physrev.physiology.org/content/94/1/189.short
+ Author Affiliations
Abstract
Brain plasticity refers to the remarkable
property of cerebral neurons to change their structure and function in
response
to experience, a fundamental theoretical theme in
the field of basic research and a major focus for neural rehabilitation
following brain disease. While much of the early
work on this topic was based on deprivation approaches relying on
sensory
experience reduction procedures, major advances
have been recently obtained using the conceptually opposite paradigm of
environmental
enrichment, whereby an enhanced stimulation is
provided at multiple cognitive, sensory, social, and motor levels. In
this
survey, we aim to review past and recent work
concerning the influence exerted by the environment on brain plasticity
processes,
with special emphasis on the underlying cellular
and molecular mechanisms and starting from experimental work on animal
models
to move to highly relevant work performed in
humans. We will initiate introducing the concept of brain plasticity and
describing
classic paradigmatic examples to illustrate how
changes at the level of neuronal properties can ultimately affect and
direct
key perceptual and behavioral outputs. Then, we
describe the remarkable effects elicited by early stressful conditions,
maternal
care, and preweaning enrichment on central nervous
system development, with a separate section focusing on
neurodevelopmental
disorders. A specific section is dedicated to the
striking ability of environmental enrichment and physical exercise to
empower
adult brain plasticity. Finally, we analyze in the
last section the ever-increasing available knowledge on the effects
elicited
by enriched living conditions on physiological and
pathological aging brain processes.
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