http://onlinelibrary.wiley.com/doi/10.1111/nan.12114/abstract
DOI: 10.1111/nan.12114
This article is protected by copyright. All rights reserved.
Issue
Neuropathology and Applied Neurobiology
Additional Information(Show All)
- This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/nan.12114
- Abstract
- Cited By
Abstract
Brain
and spinal cord injury can result in permanent cognitive, motor,
sensory and autonomic deficits. The CNS has a poor intrinsic capacity
for regeneration, although some functional recovery does occur. This is
mainly in the form of sprouting, dendritic remodelling and changes in
neuronal coding, firing and synaptic properties; elements collectively
known as plasticity. An important approach to repair the injured CNS is
therefore to harness, promote and refine plasticity. In the adult, this
is partly limited by the extracellular matrix (ECM). While the ECM
typically provides a supportive framework to CNS neurons, its role is
not only structural; the ECM is homeostatic, actively regulatory and of
great signalling importance, both directly via receptor or
co-receptor-mediated action and via spatially and temporally relevant
localisation of other signalling molecules. In an injury or disease
state, the ECM represents a key environment to support a healing and/or
regenerative response. However, there are aspects of its composition
which prove suboptimal for recovery: some molecules present in the ECM
restrict plasticity and limit repair. An important therapeutic concept
is therefore to render the ECM environment more permissive by
manipulating key components, such as inhibitory chondroitin sulphate
proteoglycans. In this review we discuss the major components of the ECM
and the role they play during development and following brain or spinal
cord injury and we consider a number of experimental strategies which
involve manipulations of the ECM, with the aim of promoting functional
recovery to the injured brain and spinal cord.
No comments:
Post a Comment