http://astore.amazon.com/alzheimerswee-20/detail/1467523690
A short writeup here:
The Madison Memory Study (MMS) was a three month long double-blinded, placebo-controlled study which assessed the effect of apoaequorin on cognitive function and other quality of life measures in adults over 40 years old with mild memory concerns associated with aging.*
The study protocol builds upon the evidence in previous pilot studies which demonstrated apoaequorin improved memory as measured by participant reported outcomes. The technology which MMS uses to measure cognitive changes in participants is a computer based assessment using software developed by CogState Ltd., a global provider of cognitive testing products and services. Participants were tested at baseline and then re-assessed four more times during the three month period.
The nine page research paper here:
The Effects of the Calcium Binding Protein Apoaequorin on Memory and Cognitive Functioning in Older Adults
Background
We report here on a double-blind, placebo controlled study designed to
assess the effect of an apoaequorin dietary supplement, compared to
placebo, on specific areas of cognitive functioning using quantitative,
computerized assessments. In recent open label and double-blind, placebo
controlled trials, older adults taking an apoaequorin dietary
supplement reported improvements in cognitive functioning. Apoaequorin
is a protein originally isolated from the jellyfish Aequorea victoria.
Methods
A
total of 218 adults, aged 40 to 91 years, who had self-reported mild
memory problems were randomly assigned to receive a 90 day supply of
either apoaequorin 10mg or a matched placebo. Participants were tested
at
predetermined time points using computer-based assessments from CogState
Ltd (www.cancog.com). Changes on specific assessments of cognitive
function were measured at various time points during the study.
Results
The apoaequorin arm showed a significant improvement in scores of
executive functioning on the Groton Maze Learning task over the 90 day
study period. In measures of learning, study participants given
apoaequorin demonstrated significantly improved recall performance at
Day 90 compared to Baseline. In an assessment of short-term memory and
learning, the Prevagen arm saw significant improvement at Day 90
compared to baseline in the One Card Learning task. The Prevagen group
also improved their ability to recall shopping list items from a
previously presented list in the International Shopping List test.
Apoaequorin was very well tolerated in this study.
Conclusion
These
results indicated a strong relationship between apoaequorin and
improvements on several quantitative measures of cognitive function.
Apoaequorin has been shown to be a well-tolerated and effective dietary
supplement for use by adults as they age. These results suggest a
supportive role for apoaequorin in improving memory for people experiencing normal age-related memory problems.
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