The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture
New brain atlas opens up alternative means for studying brain disorders
Stereoscopic Atlas of Intrinsic Brain Networks (SAIBN)
The latest here:
Comprehensive cellular-resolution atlas of the adult human brain
DOI: 10.1002/cne.24080
© 2016 Wiley Periodicals, Inc.
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- Abstract
- Cited By
Keywords:
- brain atlas;
- cerebral cortex;
- hippocampal formation;
- thalamus;
- hypothalamus;
- amygdala;
- cerebellum;
- brainstem;
- MRI;
- DWI;
- cytoarchitecture;
- parvalbumin;
- neurofilament protein;
- RRIDs: AB_10000343;
- AB_2314904;
- SCR_014329
ABSTRACT
Detailed
anatomical understanding of the human brain is essential for unraveling
its functional architecture, yet current reference atlases have major
limitations in terms of lack of whole-brain coverage, relatively low
image resolution, and sparse structural annotation. We present the first
digital human brain atlas to incorporate neuroimaging, high-resolution
histology, and chemoarchitecture across a complete adult female brain,
consisting of MRI, DWI, and 1356 large-format cellular resolution (1
µm/pixel) Nissl and immunohistochemistry anatomical plates. The atlas is
comprehensively annotated for 862 structures, including 117 white
matter tracts and several novel cyto- and chemoarchitecturally defined
structures, and these annotations were transferred onto the matching MRI
dataset. Neocortical delineations were done for sulci, gyri, and
modified Brodmann areas to link macroscopic anatomical and microscopic
cytoarchitectural parcellations. Correlated neuroimaging and
histological structural delineation allowed fine feature identification
in MRI data and subsequent structural identification in MRI data from
other brains. This interactive online digital atlas is integrated with
existing Allen Institute for Brain Science gene expression atlases and
is publicly accessible as a resource for the neuroscience community.
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