Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 12, 2018

Insilico Binding Studies of Resveratrol for Protective Effects in Neurodegeneration Using Glutamate Receptor 3B as Target Model

How fucking long before this is tested in humans?  Don't try this on your own, you have no clue how to translate resveratrol and then convert that to bottles of red wine. Our fucking failures of stroke associations will do nothing with this, just like they always do nothing with promising research.

Insilico Binding Studies of Resveratrol for Protective Effects in Neurodegeneration Using Glutamate Receptor 3B as Target Model


  • C. S. Reddy Nallagouni
    • 1
  • K. Pratap Reddy
    • 2
  1. 1.Department of ZoologyUniversity College of Science, Osmania UniversityHyderabadIndia
  2. 2.Neuroscience Lab, Department of ZoologyOsmania UniversityHyderabadIndia
Chapter
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


Abstract

Resveratrol, a phytoalexin phenolic compound found in different plants, like berries, grapes, and peanuts and studied on defensive mechanisms of neurodegeneration. Glutamate receptors are synaptic receptors, which are situated on the films of neuronal cells. Glutamate is utilized to gather proteins, however, it additionally works as a neurotransmitter and is especially copious in the sensory system. NMDA receptor 3B utilized clinically as a part of the treatment of AD and in this way it offers a fantastic apparatus to encourage translational extrapolation. In this work, we have demonstrated a three-dimensional structure for glutamate [NMDA] receptor 3B subunit utilizing MODELLER9V7 programming with 2RCA as layout. With the guide of molecular elements and molecular recreations, it was distinguished that the created structure was dependable. This structure was utilized to recognize better inhibitor utilizing docking with Resveratrol. The Resveratrol was docked to the glutamate receptor 3B structure into the dynamic site containing deposits, for example, ASP21, LEU30, TYR31, HIS59, and MET60. Our test studies can be further used to build up a superior medication for Alzheimer’s disease.

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