Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 12, 2018

This Drug Could Help People Recover Movement After A Stroke

Followup needed, but your fucking failures of stroke associations will do nothing. You're screwed.
http://www.iflscience.com/health-and-medicine/this-drug-could-help-people-recover-movement-after-a-stroke/
Scientists say they have tested a drug that could help return some functionality of movement after someone has had a stroke.
Published in the journal Science, the study was led by Yokohama City University in Japan. While the study focused on mice and monkeys, an early clinical trial has suggested the drug is safe for humans, with a full clinical trial related to this study planned for 2019.
The research looked into something called plasticity. After brain damage from a stroke, the brain can naturally rewire its connections – plasticity – with a protein called CRMP2 thought to play a role.
In this study, mice were trained to reach for food pellets, with the researchers seeing how they performed before and after a stroke. They administered a molecule called edonerpic maleate, known to target CRMP2, in varying levels to see how their performance changed.
In tandem with rehabilitation, the researchers found that administering the drug “significantly boosted the ability of the mice to perform the reaching task,” a statement noted. Monkeys were also given the same task to do, before and after a stroke, with the same results when given edonerpic maleate.
"What's interesting about this approach is that, while there's some spontaneous recovery of function, it's meant to be activated by rehabilitative therapy," Jason Hinman, a University of California, Los Angeles, neurologist who was not involved in the research, told the LA Times. "If you just sit on the couch, you don't get the benefit."
It’s estimated that every year 800,000 Americans suffer a stroke, while 1.7 million people suffer a traumatic brain injury. Finding a treatment for such brain injuries is difficult, however, and often focuses on the first few hours after the injury.
“The beauty and intricacy of the human brain is unfortunately also mirrored by its vulnerability,” Simon Rumpel, from the Johannes Gutenberg University Mainz, noted in an accompanying Perspective piece. “Damage to the brain is typically permanent.”
This drug, however, can be administered days after the incident, rather than hours, meaning it opens up a bigger window of opportunity. This particular drug has been tested before on humans and is known to be safe, so it could be a viable treatment option in the future.
“The efficacy of edonerpic maleate in humans should be evaluated in clinical trials because safety profiles of this compound have already been well established,” the researchers noted in their paper.

1 comment:

  1. Thank God these researchers are honest about their pill requiring active work from stroke survivors to have benficial effect.

    ReplyDelete