WHOM is going to follow this up with stroke research seeing if it helps stroke recovery? Since there is NO stroke leadership to talk to, NOTHING WILL BE DONE!
VEGF and Neuronal Survival
Abstract
Vascular
endothelial growth factor (VEGF) is well known for its angiogenic
activity, but recent evidence has revealed a neuroprotective action of
this factor on injured or diseased neurons. In the present review, we
summarize the most relevant findings that have contributed to establish a
link between VEGF deficiency and neuronal degeneration. At issue, 1)
mutant mice with reduced levels of VEGF show adult-onset muscle weakness
and motoneuron degeneration resembling amyotrophic lateral sclerosis
(ALS), 2) administration of VEGF to different animal models of
motoneuron degeneration improves motor performance and ameliorates
motoneuronal degeneration, and 3) there is an association between low
plasmatic levels of VEGF and human ALS. Altogether, the results
presented in this review highlight VEGF as an essential motoneuron
neurotrophic factor endowed with promising therapeutic potential for the
treatment of motoneuron disorders.
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