Your competent? doctor has been working on Uric acid a long time already, right? Oh no, you DON'T have a functioning stroke doctor, do you? And they still haven't been fired yet?
- Uric acid (11 posts to February 2014)
Increased uric acid to high-density lipoprotein ratio positively correlated with stroke risk
Tieshi Zhu
Yong He
Erxinxian Bei- 1Department of Neurology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China
- 2Department of Neurology, Liuyang Jili Hospital, Changsha, China
- 3Department of Neurology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China
Background: The Uric Acid-to-HDL Ratio (UHR), a novel index derived from serum uric acid and high-density lipoprotein, has been linked to hypertension and poor diabetes control. It has also been shown to predict ischemic heart disease and is strongly associated with collateral circulation and coronary artery flow reserve. However, fewer studies have focused on the relationship between UHR and stroke, highlighting the need for further research in this area.
Methods: The study included 33,192 individuals from the NHANES 1999–2023, of whom 1,363 had a history of stroke. The nonlinear relationship between UHR and stroke risk was assessed using restricted cubic spline (RCS) analysis, and the robustness of the findings was further tested through stratified analysis. Logistic regression was employed to analyze the relationship between UHR and stroke risk, considering both UHR as a continuous variable and its categorization into quartiles (Q1–Q4).
Results: UHR was not nonlinearly associated with stroke (p for overall <0.01; p for nonlinearity = 0.65), and the RCS graph approximated a straight line with a positive slope. UHR was significantly associated with an increased risk of stroke, both when analyzed as a continuous variable (Model 4: OR = 1.02, 95% CI 1.01–1.03, p < 0.01) and when categorized into quartiles (Q4, OR = 1.31, 95% CI 1.11–1.55, p < 0.01).
Conclusion: There was a significant positive correlation between UHR and stroke risk.
Introduction
Stroke remains a leading cause of mortality and disability worldwide, placing a substantial burden on individuals, families, and healthcare systems (1, 2). Given its unfavorable prognosis and the long-term functional impairments experienced by many survivors, a comprehensive understanding and identification of risk factors are essential for effective prevention strategies (3–5).
Traditional risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, smoking, and alcohol consumption (6–10). Beyond these established factors, elevated serum uric acid (UA) and reduced high-density lipoprotein (HDL) levels have also been implicated in stroke pathogenesis (11, 12). The Uric Acid-to-HDL Ratio (UHR) is a novel and easily accessible index that integrates these two parameters, providing a potential marker for systemic inflammatory and metabolic conditions (13, 14). Studies have demonstrated that UHR outperforms serum uric acid and HDL alone in predicting coronary artery disease and the severity of coronary stenosis (15). Furthermore, UHR has been associated with an increased risk of type 2 diabetes mellitus, metabolic syndrome, myocardial infarction, and all-cause mortality in individuals with diabetes (16–19). However, its relationship with stroke remains inadequately explored. Therefore, this study aims to investigate the association between UHR and stroke using data from the National Health and Nutrition Examination Survey (NHANES) 1999–2023, providing a foundation for future prospective research.
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