Lithium Deficiency May Spur Alzheimer’s — and Guide Treatment

 

Will your competent? doctor and hospital ENSURE RESEARCH IS CREATED that tests whether this could be used to prevent Alzheimers post stroke? Oh no, your doctor and hospital ARE DOING NOTHING!

The reason you need dementia prevention: 

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.

3. A 20% chance in this research.   July 2013. 

Parkinson’s Disease May Have Link to Stroke March 2017 

The latest here:

Lithium Deficiency May Spur Alzheimer’s — and Guide Treatment

Lithium, long prescribed for bipolar disorder and as an adjunct in depression, is essential for brain resilience, and new research suggests that deficiency of the mineral in neural tissue may contribute to Alzheimer’s disease (AD).

For the first time, investigators found that lithium is sequestered by amyloid plaques in AD, depleting its availability in neural tissue. In addition, they found that a novel lithium-based compound engineered to bypass plaque binding reversed synaptic and cognitive deficits in mouse models and has the potential to restore memory

In addition, analyses of human brain tissue showed that loss of lithium was one of the earliest changes leading up to AD. In mice with lowered lithium levels, researchers found similar accelerated brain pathology and memory decline.

Amyloid-beta (Aβ) plaques in the brain are a hallmark of AD. When they develop early in the disease, they bind to lithium, inhibiting uptake of the mineral in the brain and lead to the reduced lithium levels observed in the study.

Researchers also identified a plaque-evading lithium salt that, when administered to mouse models with AD, was associated with significantly reduced AD-type pathology and improved memory.

“We found that endogenous lithium in the brain changed during aging, and this could be recapitulated in mouse models of the disease,” coinvestigator Bruce A. Yankner, MD, Department of Genetics, Harvard Medical School, Boston, told Medscape Medical News.