Deans' stroke musings: The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 25, 2025

The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis

More useless crapola, predicting a problem; NOT SOLVING THE PROBLEM! You're fired!

The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis

Yan-qiu Wang¹

Xia He²^*

Xia-lian Huang²

Fu-li Qin¹

Feng-le Mao²

Yue-ming Cheng²

Xiao-xue Zeng¹

Ying-ying Yang¹

Ming-xi Xu¹

¹School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China
²Department of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China

Background: The role of serum albumin levels and albumin-related nutritional indices in the prediction of cognitive impairment after stroke has not reached a uniform conclusion.

Methods: This study was prospectively registered in PROSPERO (CRD420251012150) and followed the PRISMA guidelines. We systematically searched six databases with a time frame from the date of database establishment to March 29, 2025. Literature selection and data collection were conducted by two researchers. Assessment of literature quality was performed according to the Newcastle-Ottawa Scale (NOS). Weighted mean difference (WMD) with 95% confidence intervals (CIs) was used to express pooled effect sizes. The chi-square (χ2) test (Cochran’s Q) and index of inconsistency (I²) were used to detect heterogeneity.

Results: A total of 9 studies involving 2,332 stroke patients were included in this meta-analysis. The results of this study showed that serum albumin levels (WMD: −3.85; 95% CI: −5.61, −2.09; p < 0.0001), Geriatric nutritional risk index (GNRI) (WMD: −2.68; 95% CI: −4.97, −0.39; p = 0.02), and HALP (hemoglobin, albumin, lymphocyte, and platelet) scores (WMD: −10.74; 95% CI: −19.98, −1.50; p = 0.02)were significantly lower in the post-stroke cognitive impairment (PSCI) compared to the post-stroke non-cognitive impairment (PSNCI).

Conclusion: Decreased serum albumin levels and albumin-related nutritional indices (GNRI and HALP scores) have a strong correlation with PSCI, which may become important indicators for early prediction of the development of PSCI.

Systematic review registration: https://www.crd.york.ac.uk/prospero/#recordDetails, identifier, CRD420251012150.