Deans' stroke musings: MicroRNAs in neuroplasticity: a comprehensive review of mechanisms and therapeutic strategies for neurodegenerative diseases

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 25, 2025

MicroRNAs in neuroplasticity: a comprehensive review of mechanisms and therapeutic strategies for neurodegenerative diseases

Didn't your competent? doctor do something for your recovery with these years ago? NO? NO followup human testing? NOTHING? FIRE YOUR DOCTOR!

microRNA (17 posts to May 2012)

MicroRNAs in neuroplasticity: a comprehensive review of mechanisms and therapeutic strategies for neurodegenerative diseases

https://doi.org/10.1016/j.neuroscience.2025.08.034 Get rights and content

Highlights

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MicroRNAs Modulate Neuroplasticity in Models of Neurodegeneration.
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Recent miRNA Biomarkers Associated with Synaptic Function.
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Modulation of Specific miRNAs Restores Synaptic Integrity.
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Potential diagnostic and therapeutic applications of microRNAs.

Abstract

MicroRNAs (miRNAs) have emerged as key regulators of neuroplasticity, influencing essential processes such as neurogenesis, synaptogenesis, and neuroinflammatory responses. This review provides a comprehensive overview of the general roles of miRNAs in neuroplasticity and synthesizes recent insights from both preclinical and clinical studies, including transcriptomic analyses and miRNA profiling, to elucidate the molecular mechanisms by which these miRNAs modulate neuronal function. We have examined specific miRNAs, such as miR-132, miR-124, miR-134, miR-135 and miR-146a, and their roles in synaptic remodeling, neuronal differentiation, and regulation of neuroinflammation. Furthermore, we have explored the therapeutic potential of targeting these miRNAs in neurodegenerative diseases, with a focus on Alzheimer’s disease and Parkinson’s disease. The review highlights the novelty of miRNA-based interventions and innovative therapeutic delivery strategies, such as exosome-based systems, and lipid nanoparticles. Despite promising results in animal models, clinical translation remains limited due to challenges in delivery systems, off-target effects, and the need for validated biomarkers. Therefore, further studies, especially longitudinal trials in humans, are essential to advance the clinical utility of miRNA-targeted therapies in neurology.