Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, August 25, 2025

Reperfusion stroke injury and brain atrophy: a penumbra of progressive cognitive decline

 You described a problem; provided NO solution! How the hell do you still have a job in stroke?

Reperfusion stroke injury and brain atrophy: a penumbra of progressive cognitive decline


Chavda, Vishal MS, PhDa; Tunde Ayomide, Olobatoke MDb; Stary, Creed M MD, PhDc; Chaurasia, Bipin MSd,*

Author Information
Annals of Medicine & Surgery ():10.1097/MS9.0000000000003735, August 19, 2025. | DOI: 10.1097/MS9.0000000000003735
  • Open
  • PAP

Abstract

Reperfusion therapy has revolutionized ischemic stroke management, yet its potential to induce secondary reperfusion brain injury (RBI) has emerged as a critical concern. This editorial explores the mechanistic links between RBI, subsequent brain atrophy, and progressive cognitive decline. Inflammation, oxidative stress, astrocytic activation, and disruption of the neurovascular unit are implicated in this pathological continuum. Drawing from current literature, we discuss the potential role of astrocytosis in amyloid-β dynamics and highlight the urgent need for biomarkers(Biomarkers don't get you recovered! ARE YOU THAT BLITHERINGLY STUPID?) and neuroprotective strategies that extend beyond acute care(NOT RECOVERY!). Understanding these interconnections may reshape long-term stroke management and guide future research toward mitigating post-stroke neurodegeneration.


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