http://onlinelibrary.wiley.com/doi/10.1111/acps.12085/abstract;jsessionid=5167ECEF0A5F03D4EF409CB10E60BE55.d01t04?deniedAccessCustomisedMessage=&userIsAuthenticated=false
Objective
To
explore the relationship between brain-derived neurotrophic factor
(BDNF) and vascular endothelial growth factor (VEGF), cerebral deep
white matter lesions (DWMLs), and measures of white matter integrity in
patients with late-onset depression, with respect to vascular risk
factors.
Method
We
examined 22 patients with late-onset depression and 22 matched
controls. Quantification of plasma BDNF and VEGF levels were performed
with enzyme-linked immunosorbent assay (ELISA) kits. Measures of white
matter integrity comprised apparent diffusion coefficient (ADC) and
fractional anisotropy (FA), obtained by diffusion tensor imaging (DTI).
Effects of DWMLs, FA, ADC, and vascular risk factors on BDNF and VEGF
were assessed using multiple linear regression.
Results
The
BDNF and VEGF levels did not differ significantly between groups. With
pooled data for patients and controls, the BDNF level was positively
associated with both number (t = 2.14, P = 0.039) and volume (t = 2.04, P = 0.048) of prefrontal DWMLs and negatively associated with FA in prefrontal normal-appearing white matter (t = −2.40, P = 0.02), adjusted for age and gender. Smoking and hypercholesterolemia was positively associated with the BDNF (t = 2.36, P = 0.023) and VEGF levels (t = 2.28, P = 0.028), respectively.
Conclusion
Our
results suggest a role for BDNF in the complex pathophysiologic
mechanisms underlying DWMLs in both normal aging and late-onset
depression.
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