Atherosclerotic Plaque in the Left Carotid Artery Is More Vulnerable Than in the Right

Well I didn't match the distribution normality. My right carotid dissected and is now completely closed up. The clot got thrown into the MCA of my right brain causing left sided hemiparesis.

Atherosclerotic Plaque in the Left Carotid Artery Is More Vulnerable Than in the Right

1. Mariana Selwaness, MD;
2. Quirijn van den Bouwhuijsen, MD;
3. Robbert S. van Onkelen, MD;
4. Albert Hofman, MD, PhD;
5. Oscar H. Franco, MD, PhD;
6. Aad van der Lugt, MD, PhD;
7. Jolanda J. Wentzel, PhD;
8. Meike Vernooij, MD, PhD

+ Author Affiliations

1. From the Departments of Epidemiology (M.S., Q.v.d.B., R.S.v.O., A.H., O.H.F., M.V.), Radiology (Q.v.d.B., A.v.d.L., M.V.), and Cardiology (J.J.W.), Erasmus MC, Rotterdam, The Netherlands.

1. Correspondence to Meike Vernooij, MD, PhD, Erasmus MC, PO Box 2014, 3000 CA Rotterdam, The Netherlands. E-mail m.vernooij@erasmusmc.nl

Abstract

Background and Purpose—Ischemic stroke is more often diagnosed in the left hemisphere than in the right. It is unknown whether this asymmetrical prevalence relates to differences in carotid atherosclerosis. We compared atherosclerotic plaque prevalence, severity, and composition between left and right carotid arteries.

Methods—In a population-based cohort, carotid MRI scanning was performed in 1414 stroke-free participants (≥45 years). Using a multisequence MRI protocol, we assessed the prevalence, stenosis, and thickness of the plaque and its predominant component (ie, lipid core, intraplaque hemorrhage, calcification, or fibrous tissue in each carotid artery). Differences between left and right side were tested using paired t tests, McNemar test and Generalized Estimating Equation analyses.

Results—The majority (85%) of the participants had bilateral carotid plaques. Unilateral plaques were twice more prevalent on the left than on the right side (67% versus 33%; P<0.001). Plaque thickness was also greater on the left (3.1±1.2 versus 2.9±1.3 mm; P<0.001); degree of stenosis did not differ. Intraplaque hemorrhage and fibrous tissue were more prevalent on the left (9.1 versus 5.9%; P<0.001 and 45.0 versus 38.5%; P<0.001), whereas calcification occurred more often on the right (37.4 versus 31.6% at the left; P<0.001). Lipid was equally distributed.

Conclusions—Carotid atherosclerotic plaque size and composition are not symmetrically distributed. Predominance of intraplaque hemorrhage in left-sided carotid plaques suggests a greater vulnerability as opposed to right-sided plaques, which are more calcified and therefore considered more stable.