Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 30, 2014

New Technology Shows Promise for Delivery of Therapeutics to the Brain

Would this help us get drugs to the brain if we ever get some useful ones created for stroke?
http://www.alphagalileo.org/ViewItem.aspx?ItemId=146701&CultureCode=en
A new technology that may assist in the treatment of brain cancer and other neurological diseases is the subject of an article in a recent issue of the journal Technology, published by World Scientific Publishing Company http://www.worldscientific.com/doi/abs/10.1142/S2339547814500186.
According to the authors, the current medical use of chemotherapy to treat brain cancer can be inefficient because of the blood-brain-barrier that impedes the delivery of drugs out of blood vessels and into the tumor.
The researchers from the Virginia Tech – Wake Forest University School of Biomedical Engineering and Sciences described in their article that they have created “a tool for blood-barrier-brain disruption that uses bursts of sub-microsecond bipolar pulses to enhance the transfer of large molecules to the brain.”
The members of the biomedical school are: Rafael V. Davalos, associate professor of biomedical engineering; John H. Rossmeisl Jr., of the Virginia-Maryland Regional College of Veterinary Medicine; Christopher Arena, Paulo A. Garcia, and Michael B. Sano of the Bioelectromechanical Systems Laboratory; and John D. Olson of the Center for Biomolecular Imaging . Garcia is also employed by the Laboratory for Energy and Microsystems innovation at the Massachusetts Institute of Technology. Arena holds a second appointment with the Laboratory for Ultrasound Contract Agent Research at the University of North Carolina – North Carolina State University, Joint Department of Biomedical Engineering.
The new tool is called Vascular Enabled Nanosecond pulse or VEIN pulse. It will “reversibly open the blood-brain-barrier to facilitate the treatment of brain cancer,” Davalos explained.
“The sub-lethal nature of these electrical bursts indicates that the VEIN pulse may be useful for treating other neurological disorders such as Parkinson’s disease, epilepsy, and Alzheimer’s disease,” Davalos added.
In their testing, the VEIN pulse treatments were administered using minimally invasive electrodes inserted into the skull of each of the 18 anesthetized male rats. They varied the pulse duration within a burst, the total number of bursts (90 to 900), and the applied field. A key element of their success was that the pulses alternated in polarity to help eliminate muscle contractions and the need for a neuromuscular blockade.
The research was supported by the Golfers Against Cancer, the Center for Biomolecular Imaging in the Wake Forest School of Medicine, a National Science Foundation (NSF) CAREER Award, and an NSF I-Corps Award.
The next step in this research would be to move to large animal, pre-clinical trials.

Davalos has been using electrical impulses in his biomedical research since his days as a graduate student at the University of California – Berkeley. More recently, in a February 2011 article in the Journal of Clinical Oncology, Davalos, Gacia and Rossmeisl were among the authors who described a successful use of irreversible electroporation to achieve complete remission and improved quality of life in a seven-year old Labrador retriever with a large and complex tumor.

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