- PubMed, EMBASE and the Cochrane databases were searched for relevant RCTs and calculated pooled OR for 3-month mortality (safety outcome) and 3-month death or dependency (modified Rankin Scale (mRs) ≥3;efficacy outcome), in patients with acute ICH randomised to either intensive BP-lowering or standard BP-lowering treatment protocols.
- Also, the authors examined the association between treatment arm and ICH expansion at 24 hours.
- They used random effects models with DerSimonian-Laird weights.
- The authors pooled 5 eligible studies including 4360 patients with acute ICH in meta-analysis.
- Between patients randomised to intensive BP-lowering treatment and standard BP-lowering treatment, the risk of 3-month mortality was similar (OR: 0.99; 95% CI: 0.82 to 1.20, p=0.909).
- Compared with standard treatment, intensive BP-lowering treatment demonstrated a (non-significant) trend for an association with lower 3-month death or dependency risk (OR: 0.91; 95% CI: 0.80 to 1.02), p=0.106).
- Compared with standard treatment, intensive BP reduction was associated with a trend for lower risk of significant ICH expansion (OR: 0.82; 95% CI: 0.68 to 1.00, p=0.056), particularly in larger RCTs.