Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Friday, February 24, 2017

How blood can be rejuvenated

Would this obviate the need to find young blood donors?

Can we reverse the ageing process by putting young blood into older people?


How blood can be rejuvenated

Our blood stem cells generate around a thousand billion new blood cells every day. But the blood stem cells’ capacity to produce blood changes as we age. This leads to older people being more susceptible to anaemia, lowered immunity and a greater risk of developing certain kinds of blood cancer. Now for the first time, a research team at Lund University in Sweden has succeeded in rejuvenating blood stem cells with established reduced function in aging mice. The study is published in Nature Communications.
When we are young, our blood stem cells produce an even and well-balanced number of red and white blood cells according to need. As we age, however, the capacity of the blood stem cells to produce the number of blood cells we need declines.
“This type of age-related change can have major consequences as it can lead to an imbalance in stem cell production. For example, a reduced production of immune cells or excessive production of other types of cells can be a precursor to leukaemia”, explains David Bryder, who headed the study at Lund University.
Tracking old stem cells

A fundamental question was whether blood stem cells age differently within a single individual or whether all blood stem cells are equally affected by advancing age. In an initial stage, it was therefore important to genetically mark old blood stem cells, to enable the identification and tracking of those most affected by age. In the next step, these traceable cells were reprogrammed to another type of stem cell – known as iPS cells, which can generate all cells in an individual and not only blood cells. When the cells are reprogrammed, their identity is ‟re-set”; when these reprogrammed iPS cells formed new blood stem cells, the researchers observed that the re-set had entailed a rejuvenation of the cells.
“We found that there was no difference in blood-generating capacity when we compared the reprogrammed blood stem cells with healthy blood stem cells from a young mouse. This is, as far as we know, the first time someone has directly succeeded in proving that it is possible to recreate the function of young stem cells from a functionally old cellˮ, says Martin Wahlestedt, the first author of the study.
Not caused by mutations

The research team’s studies have also thereby shown that many age-related changes in the blood system cannot be explained by mutations in the cells’ DNA. If the changes depended on permanent damage at the DNA level, the damage would still be present after the re-set. Instead, epigenetic changes appear to underlie the decline in function associated with advancing age.
“Our findings justify further research to improve the function of human blood stem cells and thereby address diseases such as anaemia, leukaemia and other blood disorders”, concludes David Bryder.
The research was funded by: the Swedish Cancer Society, the Swedish Research Council, the Swedish Pediatric Leukemia Foundation, Knut and Alice Wallenberg foundation, ERC consolidator grant
http://www.nature.com/articles/ncomms14533
Full bibliographic informationClonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez & David Bryder

Nature Communications 8, Article number: 14533 (2017)
doi:10.1038/ncomms14533

AgeingHaematopoiesisHaematopoietic stem cells

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