http://circoutcomes.ahajournals.org/content/10/2/e003546?cpetoc=
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Introduction
Despite
advances in care, stroke remains a leading cause of mortality and
long-term disability around the world for both women and men.1
There are, however, notable sex differences in the epidemiology of
stroke, including differences in incidence and mortality. Across the
lifespan, women have a greater lifetime risk of stroke, a greater risk
of death from stroke, and a higher risk of poor functional outcomes
after stroke than men.2,3
A better understanding of the contributors to sex differences in stroke
mortality could lead to the identification of strategies to improve
stroke outcomes in women, as well as men. A study published in this
issue by Phan et al4 included a
meta-analysis using individual participant data from population-based
studies to examine the contributors to sex differences in long-term
mortality after stroke. The authors’ process of identifying contributors
to the sex–mortality association in individual studies before combining
data in a meta-analysis allowed them to clarify which factors
contribute to higher stroke mortality in women and to identify
potentially modifiable factors leading to poor stroke outcomes.
See Article by Phan et al
Their
study is a meta-analysis of 13 studies of stroke incidence based on
ideal population-based data sets; individual stroke incidence studies
were conducted across Europe, Australia, South America, and the
Caribbean between 1987 and 2013. Study authors examined all-cause
mortality at 1 year after incident stroke in 13 studies (almost 17 000
patients) and all-cause mortality at 5 years after stroke in 8 studies
(over 13 000 participants). Mortality rates were compared in …
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