https://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11490100
2001 Aug;12(2):75-81.
Abstract
Subjective
fatigue, defined as a feeling of early exhaustion developing during
mental activity, with weariness, lack of energy and aversion to effort,
remains virtually unstudied in patients with stroke, bur recent surveys
suggest that it is a major, commonly overlooked, stroke sequela. While
the few existing series did not show significant correlations between
fatigue and stroke severity, lesion location, cognitive and neurological
impairment and depression, recent neurobehavioral studies have
highlighted an association between fatigue and brainstem and thalamic
lesions. This suggests that fatigue may be linked to the interruption of
neural networks involved in tonic attention, such as the reticular
activating system. In fact, several subtypes of fatigue may develop
after stroke, in connection with cognitive sequelae, neurological
impairment, psychological factors and sleep disorders. A challenge is to
identify and delineate these different subtypes and to distinguish them
from mood disorders, which frequently coexist. We emphasize the concept
of 'primary' poststroke fatigue, which may develop in the absence of
depression or a significant cognitive sequela, and which may be linked
to attentional deficits resulting from specific damage to the reticular
formation and related structures involved in the subcortical attentional
network. In the patients with excellent neurological and
neuropsychological recovery, poststroke fatigue may be the only
persisting sequela, which may severely limit their return to previous
activities. The recognition of poststroke fatigue may be critical during
recovery and rehabilitation after stroke.
- PMID:
- 11490100
- DOI:
- 47685
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