Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 14214 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Thursday, February 23, 2017
Sevoflurane preconditioning induced endogenous neurogenesis against ischemic brain injury by promoting microglial activation
So when you know ahead of time when your stroke is going to occur you could take this to precondition your brain to produce neurogenesis better. Assuming of course that this is followed up with human clinical tests. https://www.ncbi.nlm.nih.gov/pubmed/28212538
ischemia causes irreversible damage to functional neurons in cases of
infarct. Promoting endogenous neurogenesis to replace necrotic neurons
is a promising therapeutic strategy for ischemia patients. The
neuroprotective role of sevoflurane preconditioning implies that it
might also enhance endogenous neurogenesis and functional restoration in
the infarct region. By using a transient middle cerebral artery
occlusion (tMCAO) model, we discovered that endogenous neurogenesis was
enhanced by sevoflurane preconditioning. This enhancement process is
characterized by the promotion of neuroblast proliferation within the
subventricular zone (SVZ), migration and differentiation into neurons,
and the presence of astrocytes and oligodendrocytes at the site of
infarct. The newborn neurons in the sevoflurane preconditioning group
showed miniature excitatory postsynaptic currents (mEPSCs), increased
synaptophysin and PSD95 staining density, indicating normal neuronal
function. Furthermore, long-term behavioral improvement was observed in
the sevoflurane preconditioning group consistent with endogenous
neurogenesis. Further histological analyses showed that sevoflurane
preconditioning accelerated microglial activation, including migration,
phagocytosis and secretion of brain-derived neurotrophic factor (BDNF).
Intraperitoneal injection of minocycline, a microglial inhibitor,
suppressed microglial activation and reversed neurogenesis. Our data
showed that sevoflurane preconditioning promoted microglial activities,
created a favorable microenvironment for endogenous neurogenesis and
accelerated functional reconstruction in the infarct region.
ischemia and reperfusion; microglia; neurogenesis; sevoflurane preconditioning; stem cells