Deans' stroke musings: Paradoxical Regulation of Copper and Zinc and Changes in Neurogenesis, Alcohol Preference and Salt Appetite in Isolated Male Rats

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, February 26, 2017

Paradoxical Regulation of Copper and Zinc and Changes in Neurogenesis, Alcohol Preference and Salt Appetite in Isolated Male Rats

No clue what this might mean for your recovery so go ask your doctor what this means.

Paradoxical Regulation of Copper and Zinc and Changes in Neurogenesis, Alcohol Preference and Salt Appetite in Isolated Male Rats

Background and Aims:

Alcohol abuse is an important concern of many societies. Hippocampal neurogenesis regulates abusing drugs in a positive manner. The aim of this study was to identify factors that regulate neurogenesis in isolation period that increase preference for alcohol and salt.

Materials and Methods:

In this study sixteen rats were randomly divided into two groups: Pair (social) and isolation. Rats in the isolation group were isolated for 14 days plus one week for acclimatization

. Rats in pair group also were kept in the same condition for 14 days. In this period BrdU (50 mg/kg/day/i.p.) was injected.

At the end of the experiment, rats examined for copper, zinc, malondialdehyde (MDA), neurogenesis, salt consumption and alcohol preference.

Results:

Zinc in serum reduced in isolated rats, but copper in serum paradoxically increased in isolated rats. Neurogenesis reduced in isolated rats. Also, MDA in serum, salt consumption, and alcohol consumption increased in the isolated group.

Conclusions:

Social isolation with reduction of neurogenesis predisposes rats to consume more alcohol and also salt. The reduction in neurogenesis is associated with paradoxical balance of zinc and copper and increase in MDA in serum. So, regulation of copper and zinc may have beneficial effects on neurogenesis, sensitization and alcohol preference.