Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 22, 2018

From Brain Ischemia to Alzheimer-Like Neurodegeneration

You'd better hope your doctor has a protocol to prevent neurodegeneration post-stroke. Or you'll have to research it all yourself.

From Brain Ischemia to Alzheimer-Like Neurodegeneration



Ryszard Pluta
, Marzena Ułamek-Kozioł
1,2
, Sławomir Januszewski
1
, Stanisław J. Czuczwar
3
1
Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences,
Warsaw, Poland
2
First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
3
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
†
Author for correspondence: Prof. Ryszard Pluta, Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical
Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Pawińskiego 5 Str., Poland, Tel: 48-22-6086-540; fax: 48-22-668-55-32;
email: pluta@imdik.pan.pl

ABSTRACT

Latest studies have revealed a key role of ischemic brain episodes in Alzheimer-like
neurodegeneration and dementia development. This review presents the current progress in
understanding how brain ischemia may promote Alzheimer’s disease pathological changes
and cognitive impairment. It seems that brain ischemia promotes Alzheimer’s disease-like
neurodegeneration development through various mechanisms, including accumulation and
aggravation of different parts of amyloid protein precursor, tau protein phosphorylation,
dysregulation of Alzheimer-related genes, neuroinflammation, neuronal loss, synaptic
dysfunction, white matter lesion and general brain atrophy. Progress in understanding
key mechanisms of ischemia-induced changes of Alzheimer-phenotype will help develop
preventing and treating strategies against sporadic Alzheimer’s disease pathology and
dementia generated by sublethal and/or silent ischemia.
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