Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 5, 2025

Resveratrol ameliorates cognitive impairment with improvement of gut microbiota, inflammation, neurogenesis, and synaptic proteins in a mouse model of Gulf War Illness

 You can't do anything with this until your competent? doctor chimes in in 50 years! Certainly not by getting resveratrol from red wine.

Resveratrol ameliorates cognitive impairment with improvement of gut microbiota, inflammation, neurogenesis, and synaptic proteins in a mouse model of Gulf War Illness

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https://doi.org/10.1016/j.ejphar.2025.177768
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Highlights

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    Resveratrol (RSV) ameliorates cognitive impairment in Gulf War Illness (GWI) mice.
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    RSV modulates gut microbiota and intestinal permeability in GWI mice.
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    RSV reduces systemic inflammation in GWI mice.
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    RSV regulates neuroinflammation, neurogenesis, and synaptic functions in GWI mice.

Abstract

The main symptoms of chronic Gulf War illness (GWI) include persistent cognition and mood impairments. Research on animals has corroborated that these cognitive and mood dysfunctions coincide with chronic neuroinflammation, declined neurogenesis, and synaptic integrity in the hippocampus. Furthermore, these neurological changes are linked with systemic inflammation and gut dysbiosis, defined by shifts in gut microbiota composition and increased intestinal permeability. Resveratrol (RSV), known for its neuroprotective properties, is currently being studied in a clinical trial for its potential to ease the symptoms in GWI veterans. Herein, we investigated whether RSV would improve cognitive and mood function in a mouse model of GWI and delved into the underlying mechanisms at play. Five months after exposure to 0.7 mg/kg pyridostigmine bromide (PB) and 200 mg/kg permethrin (PER), a two-week regimen of RSV at doses of 20 or 40 mg/kg alleviated the cognitive deficits observed in the object location and novel object recognition tests. RSV treatment effectively mitigates cognitive disorders through multiple mechanisms: (1) amelioration of gut microbiota dysbiosis and intestinal permeability; (2) downregulation of serum proinflammatory cytokine levels; (3) suppression of chronic neuroinflammation in the hippocampus, evidenced by reduced astrocyte hypertrophy, microglial activation, and neuroinflammatory markers; (4) promotion of hippocampal neurogenesis; and (5) normalization of synaptic protein levels, including PSD95, CaMKIIα. This study provides novel insights into the potential of RSV to alleviate cognitive impairment, alongside the restoration of gut dysbiosis, in veterans suffering from GWI.
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