http://www.neurology.org/content/early/2013/10/09/WNL.0b013e3182a9f45f
- Ramon Luengo-Fernandez, DPhil,
- Alastair M. Gray, PhD,
- Linda Bull, RGN,
- Sarah Welch, RGN,
- Fiona Cuthbertson, MCSP,
- Peter M. Rothwell, FMedSci;
- For the Oxford Vascular Study
- Correspondence to Prof. Rothwell: peter.rothwell@ndcn.ox.ac.uk
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10.1212/WNL.0b013e3182a9f45fNeurology
- Abstract
- Full Text (PDF)
- Also available:
- Data Supplement
Abstract
Objective: To evaluate the 5-year impact of stroke and TIA on utility and quality-adjusted survival.
Methods: TIA and
stroke patients from a UK population-based study (Oxford Vascular Study)
were recruited from 2002 to 2007, and followed
up until 2012. Quality of life was assessed over
5 years using the EQ-5D (EuroQol-5 Dimensions), with responses
converted
into utilities ranging from −0.59 (worse than
death) to 1 (perfect health), using UK population valuations. Utilities
for
stroke and TIA patients were compared with those
in matched controls obtained from the 2006 Health Survey for England.
Five-year
quality-adjusted life years were estimated by
combining utility and survival information.
Results: Four hundred forty TIA and 748 stroke patients were ascertained and included. Utility remained constant at approximately
0.78 over the 5 years after TIA. Utility improved from 0.64 one month after stroke to 0.70 at 6 months (p = 0.006), remaining at approximately 0.70 thereafter. Matched controls had considerably higher utility levels than stroke/TIA
patients (0.85, p < 0.001). Event
severity and recurrent stroke were significant predictors of decreased
long-term utility. Five-year quality-adjusted
life expectancy was 3.32 (95% confidence
interval: 3.22–3.48) quality-adjusted life years after TIA and 2.21
(2.15–2.37) after
stroke, varying considerably by severity (minor:
2.94; moderate: 1.65; and severe: 0.70).
Conclusion:
Quality-adjusted survival is low over the 5 years after stroke and TIA,
with severity and recurrent stroke being major predictors.
There remains considerable scope for
improvements in acute treatment and secondary prevention to improve the
quality of life
after TIA and stroke.
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